Source:http://linkedlifedata.com/resource/pubmed/id/16755275
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
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| pubmed:dateCreated |
2006-7-26
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| pubmed:abstractText |
Obsessive-compulsive disorder (OCD) is the tenth most disabling medical condition worldwide. Twin and family studies implicate a genetic etiology for this disorder, although specific genes have yet to be identified. Here, we present the first large-scale model-free linkage analysis of both extended and nuclear families using both 'broad' (definite and probable diagnoses) and 'narrow' (definite only) definitions of OCD. We conducted a genome-scan analysis of 219 families collected as part of the OCD Collaborative Genetics Study. Suggestive linkage signals were revealed by multipoint analysis on chromosomes 3q27-28 (P=0.0003), 6q (P=0.003), 7p (P=0.001), 1q (P=0.003), and 15q (P=0.006). Using the 'broad' OCD definition, we observed the strongest evidence for linkage on chromosome 3q27-28. The maximum overall Kong and Cox LODall score (2.67) occurred at D3S1262 and D3S2398, and simulation based P-values for these two signals were 0.0003 and 0.0004, respectively, although for both signals, the simulation-based genome-wide significance levels were 0.055. Covariate-linkage analyses implicated a possible role of gene(s) on chromosome 1 in increasing the risk for an earlier onset form of OCD. We are currently pursuing fine mapping in the five regions giving suggestive signals, with a particular focus on 3q27-28. Given probable etiologic heterogeneity in OCD, mapping gene(s) involved in the disorder may be enhanced by replication studies, large-scale family-based linkage studies, and the application of novel statistical methods.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:status |
MEDLINE
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| pubmed:month |
Aug
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| pubmed:issn |
1359-4184
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| pubmed:author |
pubmed-author:BienvenuO JOJ,
pubmed-author:CullenBB,
pubmed-author:FyerA JAJ,
pubmed-author:GradosM AMA,
pubmed-author:GreenbergB DBD,
pubmed-author:Hoehn-SaricRR,
pubmed-author:KnowlesJ AJA,
pubmed-author:LiangK-YKY,
pubmed-author:McCrackenJ TJT,
pubmed-author:MurphyD LDL,
pubmed-author:NestadtGG,
pubmed-author:PageJJ,
pubmed-author:PaulsD LDL,
pubmed-author:PiacentiniJJ,
pubmed-author:PintoAA,
pubmed-author:RasmussenS ASA,
pubmed-author:RauchS LSL,
pubmed-author:RiddleM AMA,
pubmed-author:SamuelsJJ,
pubmed-author:ShugartY YYY,
pubmed-author:ValleDD,
pubmed-author:WangYY,
pubmed-author:WillourV LVL
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| pubmed:issnType |
Print
|
| pubmed:volume |
11
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
763-70
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:16755275-Chromosomes, Human,
pubmed-meshheading:16755275-Chromosomes, Human, Pair 1,
pubmed-meshheading:16755275-Chromosomes, Human, Pair 15,
pubmed-meshheading:16755275-Chromosomes, Human, Pair 3,
pubmed-meshheading:16755275-Chromosomes, Human, Pair 6,
pubmed-meshheading:16755275-Chromosomes, Human, Pair 7,
pubmed-meshheading:16755275-Family Health,
pubmed-meshheading:16755275-Genetic Predisposition to Disease,
pubmed-meshheading:16755275-Genome, Human,
pubmed-meshheading:16755275-Genomics,
pubmed-meshheading:16755275-Humans,
pubmed-meshheading:16755275-Lod Score,
pubmed-meshheading:16755275-Obsessive-Compulsive Disorder,
pubmed-meshheading:16755275-Phenotype
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| pubmed:year |
2006
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| pubmed:articleTitle |
Genomewide linkage scan for obsessive-compulsive disorder: evidence for susceptibility loci on chromosomes 3q, 7p, 1q, 15q, and 6q.
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| pubmed:affiliation |
Department of Epidemiology, Johns Hopkins University, Baltimore, MD 21287, USA. yyao@jhsph.edu
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|