Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2006-6-6
pubmed:abstractText
Recent studies have suggested that aldosterone plays a role in the pathogenesis of renal injury. In this study, we investigated whether local angiotensin II (Ang II) activity contributes to the progression of renal injury in aldosterone/salt-induced hypertensive rats. Uninephrectomized rats were treated with 1% NaCl in a drinking solution and one of the following combinations for 6 weeks: vehicle (2% ethanol, s.c.; n=9), aldosterone (0.75 mug/h, s.c.; n=8), aldosterone+Ang II type 1 receptor blocker olmesartan (10 mg/kg/day, p.o.; n=8), or aldosterone+olmesartan (100 mg/kg/day, p.o.; n=9). Aldosterone/salt-treated hypertensive rats exhibited severe proteinuria and renal injury characterized by glomerular sclerosis and tubulointerstitial fibrosis. Aldosterone/salt-induced renal injury was associated with augmented expression of angiotensin converting enzyme and Ang II levels in the renal cortex and medullary tissues. Renal cortical and medullary mRNA expression of transforming growth factor-beta (TGF-beta) and connective tissue growth factor (CTGF) as well as the collagen contents were increased in aldosterone/salt-treated hypertensive rats. Treatment with olmesartan (10 or 100 mg/kg/day) had no effect on blood pressure but attenuated proteinuria in a dose-dependent manner. Olmesartan at 10 mg/kg/day tended to decrease renal cortical and medullary Ang II levels, TGF-beta and CTGF expression, and collagen contents; however, these changes were not significant. On the other hand, an ultrahigh dose of olmesartan (100 mg/kg/day) significantly decreased these values and ameliorated renal injury. These data suggest that augmented local Ang II activity contributes, at least partially, to the progression of aldosterone/salt-dependent renal injury.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Aldosterone, http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin II, http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin II Type 1 Receptor..., http://linkedlifedata.com/resource/pubmed/chemical/Collagen, http://linkedlifedata.com/resource/pubmed/chemical/Connective Tissue Growth Factor, http://linkedlifedata.com/resource/pubmed/chemical/Creatine, http://linkedlifedata.com/resource/pubmed/chemical/Ctgf protein, rat, http://linkedlifedata.com/resource/pubmed/chemical/Imidazoles, http://linkedlifedata.com/resource/pubmed/chemical/Immediate-Early Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Signaling Peptides..., http://linkedlifedata.com/resource/pubmed/chemical/Peptidyl-Dipeptidase A, http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Angiotensin, Type 1, http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Angiotensin, Type 2, http://linkedlifedata.com/resource/pubmed/chemical/Sodium Chloride, http://linkedlifedata.com/resource/pubmed/chemical/Tetrazoles, http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta, http://linkedlifedata.com/resource/pubmed/chemical/olmesartan
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0916-9636
pubmed:author
pubmed:issnType
Print
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
169-78
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:16755152-Aldosterone, pubmed-meshheading:16755152-Angiotensin II, pubmed-meshheading:16755152-Angiotensin II Type 1 Receptor Blockers, pubmed-meshheading:16755152-Animals, pubmed-meshheading:16755152-Blood Pressure, pubmed-meshheading:16755152-Body Weight, pubmed-meshheading:16755152-Collagen, pubmed-meshheading:16755152-Connective Tissue Growth Factor, pubmed-meshheading:16755152-Creatine, pubmed-meshheading:16755152-Hypertension, pubmed-meshheading:16755152-Imidazoles, pubmed-meshheading:16755152-Immediate-Early Proteins, pubmed-meshheading:16755152-Intercellular Signaling Peptides and Proteins, pubmed-meshheading:16755152-Kidney, pubmed-meshheading:16755152-Male, pubmed-meshheading:16755152-Nephrectomy, pubmed-meshheading:16755152-Organ Size, pubmed-meshheading:16755152-Peptidyl-Dipeptidase A, pubmed-meshheading:16755152-Proteinuria, pubmed-meshheading:16755152-Rats, pubmed-meshheading:16755152-Rats, Sprague-Dawley, pubmed-meshheading:16755152-Receptor, Angiotensin, Type 1, pubmed-meshheading:16755152-Receptor, Angiotensin, Type 2, pubmed-meshheading:16755152-Sodium Chloride, pubmed-meshheading:16755152-Tetrazoles, pubmed-meshheading:16755152-Transforming Growth Factor beta
pubmed:year
2006
pubmed:articleTitle
Augmentation of intrarenal angiotensin II levels in uninephrectomized aldosterone/salt-treated hypertensive rats; renoprotective effects of an ultrahigh dose of olmesartan.
pubmed:affiliation
Department of Pharmacology, Kagawa University Medical School, Kagawa, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't