|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
2006-6-13
|
|
pubmed:abstractText |
It is well established that the pre-T cell receptor for antigen (TCR) is responsible for efficient expansion and differentiation of thymocytes with productive TCRbeta rearrangements. However, Ptcra- as well as Tcra-targeting experiments have suggested that the early expression of Tcra in CD4- CD8- cells can partially rescue the development of alphabeta CD4+ CD8+ cells in Ptcra-deficient mice. In this study, we show that the TCR E delta but not E alpha enhancer function is required for the cell surface expression of alphabetaTCR on immature CD4- CD8- T cell precursors, which play a crucial role in promoting alphabeta T cell development in the absence of pre-TCR. Thus, alphabetaTCR expression by CD4- CD8- thymocytes not only represents a transgenic artifact but occurs under physiological conditions.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16754716,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16754716-10367896,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16754716-10382759,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16754716-10403647,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16754716-10523607,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16754716-10952723,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16754716-12119351,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16754716-12925850,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16754716-14993248,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16754716-15246254,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16754716-15470049,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16754716-15963785,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16754716-15998791,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16754716-1608941,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16754716-1834758,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16754716-2439914,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16754716-7596413,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16754716-7903854,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16754716-7973703,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16754716-8402912,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16754716-8885867,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16754716-9143699,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16754716-9151891,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16754716-9354471,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16754716-9541576,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16754716-9646843,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16754716-9850856
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
0022-1007
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
12
|
|
pubmed:volume |
203
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1543-50
|
|
pubmed:dateRevised |
2010-12-3
|
|
pubmed:meshHeading |
pubmed-meshheading:16754716-Animals,
pubmed-meshheading:16754716-Artifacts,
pubmed-meshheading:16754716-CD4-Positive T-Lymphocytes,
pubmed-meshheading:16754716-CD8-Positive T-Lymphocytes,
pubmed-meshheading:16754716-Enhancer Elements, Genetic,
pubmed-meshheading:16754716-Gene Rearrangement, T-Lymphocyte,
pubmed-meshheading:16754716-Membrane Glycoproteins,
pubmed-meshheading:16754716-Mice,
pubmed-meshheading:16754716-Mice, Inbred C57BL,
pubmed-meshheading:16754716-Mice, Knockout,
pubmed-meshheading:16754716-Mice, Transgenic,
pubmed-meshheading:16754716-Organ Culture Techniques,
pubmed-meshheading:16754716-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:16754716-T-Lymphocytes,
pubmed-meshheading:16754716-Thymus Gland
|
|
pubmed:year |
2006
|
|
pubmed:articleTitle |
The E delta enhancer controls the generation of CD4- CD8- alphabetaTCR-expressing T cells that can give rise to different lineages of alphabeta T cells.
|
|
pubmed:affiliation |
Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|
