Linked Life Data

16753187

Source:http://linkedlifedata.com/resource/pubmed/id/16753187

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2006-6-23
pubmed:abstractText
Human depression is partly a congenital disorder. Aspects of the behavior accompanying depression can be magnified by genetic manipulation of bred animal species. Learned Helplessness (LH) is a trait-mark behavior that successfully breeds in rodents. Here, 'congenital' LH (cLH) rats were trained to recognize and respond to 12s long interval cues (irt>12s schedule). Rats compliant to an irt>t schedule will space responses evenly and respond rhythmically. Irt>t schedule derived data are plotted in histograms showing irt (interresponse time) frequencies. A pause response peak emerges, for outbred rats, at irt values approximating the minimum interval for reinforcement. cLH rats [n=9] complied poorly to schedule contingencies when diluent (vehicle) was injected before testing. Moderate and high dose injections of a CB 1 receptor selective agonist drug (AM 411), however, increased operant schedule compliance and normalized the cLH rats' irt>t histogram distributions. Performance indicators for cLH rats are presented alongside coordinate measures from a comparison group [n=5] of normally bred Sprague-Dawley (SD) rats. In both cLH and SD rats, treatment session histograms revealed shifts of the pause response peak not accompanied by a change in motor responsiveness. The irt>12s histogram shifts were absent when AM 411 dosages were arranged to follow pre-medication injections of a CB 1 receptor selective antagonist drug (AM 251). In short, AM 411 increased timing acuity in rats prone to behavioral despair but had opposite timing effects in normally bred SD rats.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0028-3908
pubmed:author
pubmed:issnType
Print
pubmed:volume
51
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
90-101
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Irt>t schedule controlled behavior in 'learned-helpless' rats: effects from a cannabinoid agonist.
pubmed:affiliation
University of Maryland, School of Pharmacy, Department of Pharmaceutical Sciences, Baltimore, MD 21201, USA. cwillmor@rx.umaryland.edu
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural