16752569

Source:http://linkedlifedata.com/resource/pubmed/id/16752569

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0180488, umls-concept:C0450363, umls-concept:C1880022
pubmed:issue	5
pubmed:dateCreated	2006-6-6
pubmed:abstractText	The development of intensity-modulated radiotherapy (IMRT) has created a clear need for a dosimeter that can accurately and conveniently measure dose distributions in three dimensions to assure treatment quality. PRESAGE is a new three dimensional (3D) dosimetry material consisting of an optically clear polyurethane matrix, containing a leuco dye that exhibits a radiochromic response when exposed to ionizing radiation. A number of potential advantages accrue over other gel dosimeters, including insensitivity to oxygen, radiation induced light absorption contrast rather than scattering contrast, and a solid texture amenable to machining to a variety of shapes and sizes without the requirement of an external container. In this paper, we introduce an efficient method to investigate the basic properties of a 3D dosimetry material that exhibits an optical dose response. The method is applied here to study the key aspects of the optical dose response of PRESAGE: linearity, dose rate dependency, reproducibility, stability, spectral changes in absorption, and temperature effects. PRESAGE was prepared in 1 x 1 x 4.5 cm3 optical cuvettes for convenience and was irradiated by both photon and electron beams to different doses, dose rates, and energies. Longer PRESAGE columns (2 x 2 x 13 cm3) were formed without an external container, for measurements of photon and high energy electron depth-dose curves. A linear optical scanning technique was used to detect the depth distribution of radiation induced optical density (OD) change along the PRESAGE columns and cuvettes. Measured depth-OD curves were compared with percent depth dose (PDD). Results indicate that PRESAGE has a linear optical response to radiation dose (with a root mean square error of -1%), little dependency on dose rate (-2%), high intrabatch reproducibility (< 2%), and can be stable (-2%) during 2 hours to 2 days post irradiation. Accurate PRESAGE dosimetry requires temperature control within 1 degrees C. Variations in the PRESAGE formulation yield corresponding variations in sensitivity, stability, and density. CT numbers in the range 100-470 were observed. In conclusion, the small volume studies presented here indicate PRESAGE to be a promising, versatile, and practical new dosimetry material with applicability for radiation therapy.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/R01 CA100835-02, http://linkedlifedata.com/resource/pubmed/grant/R01 CA100835-03
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/16752569-10473200, http://linkedlifedata.com/resource/pubmed/commentcorrection/16752569-10473201, http://linkedlifedata.com/resource/pubmed/commentcorrection/16752569-10795984, http://linkedlifedata.com/resource/pubmed/commentcorrection/16752569-11458569, http://linkedlifedata.com/resource/pubmed/commentcorrection/16752569-11488576, http://linkedlifedata.com/resource/pubmed/commentcorrection/16752569-12722814, http://linkedlifedata.com/resource/pubmed/commentcorrection/16752569-12852548, http://linkedlifedata.com/resource/pubmed/commentcorrection/16752569-12945992, http://linkedlifedata.com/resource/pubmed/commentcorrection/16752569-14761019, http://linkedlifedata.com/resource/pubmed/commentcorrection/16752569-15028408, http://linkedlifedata.com/resource/pubmed/commentcorrection/16752569-15191297, http://linkedlifedata.com/resource/pubmed/commentcorrection/16752569-15528070, http://linkedlifedata.com/resource/pubmed/commentcorrection/16752569-8971964, http://linkedlifedata.com/resource/pubmed/commentcorrection/16752569-9044414, http://linkedlifedata.com/resource/pubmed/commentcorrection/16752569-9279907, http://linkedlifedata.com/resource/pubmed/commentcorrection/16752569-9623644, http://linkedlifedata.com/resource/pubmed/commentcorrection/16752569-9775382, http://linkedlifedata.com/resource/pubmed/commentcorrection/16752569-9814511
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0425746
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	May
pubmed:issn	0094-2405
pubmed:author	pubmed-author:AdamovicsJ AJA, pubmed-author:GuyP SPS, pubmed-author:OldhamMM
pubmed:issnType	Print
pubmed:volume	33
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	1338-45
pubmed:dateRevised	2011-9-26
pubmed:meshHeading	pubmed-meshheading:16752569-Dose-Response Relationship, Radiation, pubmed-meshheading:16752569-Equipment Design, pubmed-meshheading:16752569-Equipment Failure Analysis, pubmed-meshheading:16752569-Imaging, Three-Dimensional, pubmed-meshheading:16752569-Radiation Dosage, pubmed-meshheading:16752569-Radiometry, pubmed-meshheading:16752569-Reproducibility of Results, pubmed-meshheading:16752569-Sensitivity and Specificity, pubmed-meshheading:16752569-Tomography, Optical, pubmed-meshheading:16752569-X-Rays
pubmed:year	2006
pubmed:articleTitle	Characterization of a new radiochromic three-dimensional dosimeter.
pubmed:affiliation	Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA.
pubmed:publicationType	Journal Article, Research Support, N.I.H., Extramural