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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2006-6-5
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pubmed:abstractText |
ATP-sensitive K(+) (K(ATP)) channels located on the beta cell plasma membrane play a critical role in regulating insulin secretion and are targets for the sulfonylurea class of antihyperglycaemic drugs. Recent reports suggest that these channels may also reside on insulin-containing dense-core vesicles and mitochondria. The aim of this study was to explore these possibilities and to test the hypothesis that vesicle-resident channels play a role in the control of organellar Ca(2+) concentration or pH.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0012-186X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
49
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1567-77
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:16752175-ATP-Binding Cassette Transporters,
pubmed-meshheading:16752175-Animals,
pubmed-meshheading:16752175-Calcium,
pubmed-meshheading:16752175-Cells, Cultured,
pubmed-meshheading:16752175-Homeostasis,
pubmed-meshheading:16752175-Hydrogen-Ion Concentration,
pubmed-meshheading:16752175-Insulin-Secreting Cells,
pubmed-meshheading:16752175-Ion Transport,
pubmed-meshheading:16752175-Membrane Potential, Mitochondrial,
pubmed-meshheading:16752175-Mice,
pubmed-meshheading:16752175-Multidrug Resistance-Associated Proteins,
pubmed-meshheading:16752175-Organelles,
pubmed-meshheading:16752175-Potassium,
pubmed-meshheading:16752175-Potassium Channels, Inwardly Rectifying,
pubmed-meshheading:16752175-Receptors, Drug,
pubmed-meshheading:16752175-Secretory Vesicles,
pubmed-meshheading:16752175-Tissue Distribution
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pubmed:year |
2006
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pubmed:articleTitle |
Intracellular ATP-sensitive K+ channels in mouse pancreatic beta cells: against a role in organelle cation homeostasis.
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pubmed:affiliation |
Henry Wellcome Laboratories for Integrated Cell Signalling and Department of Biochemistry, School of Medical Sciences, University of Bristol, University Walk, Bristol, BS8 1TD, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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