| pubmed-article:16751601 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16751601 | lifeskim:mentions | umls-concept:C0039062 | lld:lifeskim |
| pubmed-article:16751601 | lifeskim:mentions | umls-concept:C1422243 | lld:lifeskim |
| pubmed-article:16751601 | lifeskim:mentions | umls-concept:C0535719 | lld:lifeskim |
| pubmed-article:16751601 | lifeskim:mentions | umls-concept:C0439855 | lld:lifeskim |
| pubmed-article:16751601 | lifeskim:mentions | umls-concept:C0376315 | lld:lifeskim |
| pubmed-article:16751601 | lifeskim:mentions | umls-concept:C0392752 | lld:lifeskim |
| pubmed-article:16751601 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:16751601 | pubmed:dateCreated | 2006-6-5 | lld:pubmed |
| pubmed-article:16751601 | pubmed:abstractText | Membrane-associated guanylate kinase inverted (MAGI)-1 plays a role as a scaffold at cell junctions in non-neuronal cells, while S-SCAM, its neuronal isoform, is involved in the organization of synapses. A search for MAGI-1-interacting proteins by yeast two-hybrid screening of a kidney cDNA library yielded dendrin. As dendrin was originally reported as a brain-specific postsynaptic protein, we tested the interaction between dendrin and S-SCAM and revealed that dendrin binds to the WW domains of S-SCAM. Dendrin is known to be dendritically translated but its function is largely unknown. To gain insights into the physiological meaning of the interaction, we performed a second yeast two-hybrid screening using dendrin as a bait. We identified CIN85, an endocytic scaffold protein, as a putative dendrin-interactor. Immunocytochemistry and subcellular fractionation analysis supported the synaptic localization of CIN85. The first SH3 domain and the C-terminal region of CIN85 bind to the proline-rich region and the N-terminal region of dendrin, respectively. In vitro experiments suggest that dendrin forms a ternary complex with CIN85 and S-SCAM and that this complex formation facilitates the recruitment of dendrin and S-SCAM to vesicle-like structures where CIN85 is accumulated. | lld:pubmed |
| pubmed-article:16751601 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16751601 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16751601 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16751601 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16751601 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16751601 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16751601 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16751601 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16751601 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16751601 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16751601 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16751601 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16751601 | pubmed:month | May | lld:pubmed |
| pubmed-article:16751601 | pubmed:issn | 0021-924X | lld:pubmed |
| pubmed-article:16751601 | pubmed:author | pubmed-author:IkedaMitsunob... | lld:pubmed |
| pubmed-article:16751601 | pubmed:author | pubmed-author:IidaJunkoJ | lld:pubmed |
| pubmed-article:16751601 | pubmed:author | pubmed-author:HataYutakaY | lld:pubmed |
| pubmed-article:16751601 | pubmed:author | pubmed-author:MoriHirokiH | lld:pubmed |
| pubmed-article:16751601 | pubmed:author | pubmed-author:SatoYujiY | lld:pubmed |
| pubmed-article:16751601 | pubmed:author | pubmed-author:HirabayashiSu... | lld:pubmed |
| pubmed-article:16751601 | pubmed:author | pubmed-author:KawataAkiraA | lld:pubmed |
| pubmed-article:16751601 | pubmed:author | pubmed-author:KansakuAiA | lld:pubmed |
| pubmed-article:16751601 | pubmed:author | pubmed-author:FujiwaraNaoyu... | lld:pubmed |
| pubmed-article:16751601 | pubmed:author | pubmed-author:SumitaKazutak... | lld:pubmed |
| pubmed-article:16751601 | pubmed:author | pubmed-author:RokukawaChiak... | lld:pubmed |
| pubmed-article:16751601 | pubmed:author | pubmed-author:HamanoMamikoM | lld:pubmed |
| pubmed-article:16751601 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16751601 | pubmed:volume | 139 | lld:pubmed |
| pubmed-article:16751601 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16751601 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16751601 | pubmed:pagination | 931-9 | lld:pubmed |
| pubmed-article:16751601 | pubmed:dateRevised | 2011-7-12 | lld:pubmed |
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| pubmed-article:16751601 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16751601 | pubmed:articleTitle | CIN85 is localized at synapses and forms a complex with S-SCAM via dendrin. | lld:pubmed |
| pubmed-article:16751601 | pubmed:affiliation | Department of Medical Biochemistry, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo 113-8519. | lld:pubmed |
| pubmed-article:16751601 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16751601 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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