Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
24
pubmed:dateCreated
2006-6-14
pubmed:databankReference
pubmed:abstractText
The fibrous collagens are ubiquitous in animals and form the structural basis of all mammalian connective tissues, including those of the heart, vasculature, skin, cornea, bones, and tendons. However, in comparison with what is known of their production, turnover and physiological structure, very little is understood regarding the three-dimensional arrangement of collagen molecules in naturally occurring fibrils. This knowledge may provide insight into key biological processes such as fibrillo-genesis and tissue remodeling and into diseases such as heart disease and cancer. Here we present a crystallographic determination of the collagen type I supermolecular structure, where the molecular conformation of each collagen segment found within the naturally occurring crystallographic unit cell has been defined (P1, a approximately 40.0 A, b approximately 27.0 A, c approximately 678 A, alpha approximately 89.2 degrees , beta approximately 94.6 degrees , gamma approximately 105.6 degrees ; reflections: 414, overlapping, 232, and nonoverlapping, 182; resolution, 5.16 A axial and 11.1 A equatorial). This structure shows that the molecular packing topology of the collagen molecule is such that packing neighbors are arranged to form a supertwisted (discontinuous) right-handed microfibril that interdigitates with neighboring microfibrils. This interdigitation establishes the crystallographic superlattice, which is formed of quasihexagonally packed collagen molecules. In addition, the molecular packing structure of collagen shown here provides information concerning the potential modes of action of two prominent molecules involved in human health and disease: decorin and the Matrix Metallo-Proteinase (MMP) collagenase.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/16751282-10222271, http://linkedlifedata.com/resource/pubmed/commentcorrection/16751282-11278347, http://linkedlifedata.com/resource/pubmed/commentcorrection/16751282-11390960, http://linkedlifedata.com/resource/pubmed/commentcorrection/16751282-11469863, http://linkedlifedata.com/resource/pubmed/commentcorrection/16751282-11874457, http://linkedlifedata.com/resource/pubmed/commentcorrection/16751282-12064927, http://linkedlifedata.com/resource/pubmed/commentcorrection/16751282-12601001, http://linkedlifedata.com/resource/pubmed/commentcorrection/16751282-12659847, http://linkedlifedata.com/resource/pubmed/commentcorrection/16751282-13223765, http://linkedlifedata.com/resource/pubmed/commentcorrection/16751282-14173005, http://linkedlifedata.com/resource/pubmed/commentcorrection/16751282-14660661, http://linkedlifedata.com/resource/pubmed/commentcorrection/16751282-15291816, http://linkedlifedata.com/resource/pubmed/commentcorrection/16751282-15501918, http://linkedlifedata.com/resource/pubmed/commentcorrection/16751282-15778444, http://linkedlifedata.com/resource/pubmed/commentcorrection/16751282-15818737, http://linkedlifedata.com/resource/pubmed/commentcorrection/16751282-19690380, http://linkedlifedata.com/resource/pubmed/commentcorrection/16751282-2926822, http://linkedlifedata.com/resource/pubmed/commentcorrection/16751282-3586015, http://linkedlifedata.com/resource/pubmed/commentcorrection/16751282-4173353, http://linkedlifedata.com/resource/pubmed/commentcorrection/16751282-514368, http://linkedlifedata.com/resource/pubmed/commentcorrection/16751282-6864807, http://linkedlifedata.com/resource/pubmed/commentcorrection/16751282-7306686, http://linkedlifedata.com/resource/pubmed/commentcorrection/16751282-7537830, http://linkedlifedata.com/resource/pubmed/commentcorrection/16751282-7612808, http://linkedlifedata.com/resource/pubmed/commentcorrection/16751282-7657652, http://linkedlifedata.com/resource/pubmed/commentcorrection/16751282-7695699, http://linkedlifedata.com/resource/pubmed/commentcorrection/16751282-7780173, http://linkedlifedata.com/resource/pubmed/commentcorrection/16751282-8673326, http://linkedlifedata.com/resource/pubmed/commentcorrection/16751282-8837012, http://linkedlifedata.com/resource/pubmed/commentcorrection/16751282-8943211, http://linkedlifedata.com/resource/pubmed/commentcorrection/16751282-9024701, http://linkedlifedata.com/resource/pubmed/commentcorrection/16751282-9466908
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:day
13
pubmed:volume
103
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
9001-5
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Microfibrillar structure of type I collagen in situ.
pubmed:affiliation
Center for Synchrotron Radiation Research and Instrumentation, Department of Biological, Chemical, and Physical Sciences, Illinois Institute of Technology, 3101 South Dearborn Street, Chicago, IL 60616, USA. orgel@lit.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural