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rdf:type |
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lifeskim:mentions |
umls-concept:C0015127,
umls-concept:C0017262,
umls-concept:C0025568,
umls-concept:C0030274,
umls-concept:C0185117,
umls-concept:C0205322,
umls-concept:C1314792,
umls-concept:C1367307,
umls-concept:C1826562,
umls-concept:C1879547,
umls-concept:C2911684
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pubmed:issue |
11
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pubmed:dateCreated |
2006-6-5
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pubmed:abstractText |
The transcription factor pancreatic and duodenal homeobox factor 1 (PDX-1) is expressed in pancreatic progenitor cells. In exocrine pancreas, PDX-1 is down-regulated during late development, while re-up-regulation of PDX-1 has been reported in pancreatic cancer and pancreatitis. To determine whether sustained expression of PDX-1 could affect pancreas development, PDX-1 was constitutively expressed in all pancreatic lineages by transgenic approaches. The transgenic pancreas was markedly small with the replacement of acinar cells by duct-like structures, accompanied by activated Stat3. Genetic ablation of Stat3 in the transgenic pancreas profoundly suppressed the metaplastic phenotype. These results provide a mechanism of pancreatic metaplasia by which persistent PDX-1 expression cell-autonomously induces acinar-to-ductal transition through Stat3 activation.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16751181-10537169,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16751181-10579983,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16751181-10952464,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16751181-11423476,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16751181-11948915,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16751181-11973276,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16751181-11994739,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16751181-12094230,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16751181-12185368,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16751181-12454861,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16751181-12671899,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16751181-12947327,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16751181-12949733,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16751181-14550306,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16751181-14706336,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16751181-14960508,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16751181-15765408,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16751181-15887112,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16751181-16020518,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16751181-16126192,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16751181-16418487,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16751181-1660837,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16751181-2982487,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16751181-7867492,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16751181-7901001,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16751181-7935793,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16751181-8631275,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16751181-9181474,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16751181-9220428,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16751181-9315659,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16751181-9710595,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16751181-9794394,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16751181-9797382,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16751181-9916792
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0890-9369
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pubmed:author |
pubmed-author:AkiraShizuoS,
pubmed-author:FujitaniYoshioY,
pubmed-author:KajimotoYoshitakaY,
pubmed-author:KanetoHideakiH,
pubmed-author:KatoKenK,
pubmed-author:KawaguchiYoshiyaY,
pubmed-author:MatsuokaTaka-akiTA,
pubmed-author:MiyatsukaTakeshiT,
pubmed-author:NakamuraYumikoY,
pubmed-author:SandgrenEric PEP,
pubmed-author:ShiraiwaToshihikoT,
pubmed-author:TakedaKiyoshiK,
pubmed-author:WrightChristopher V ECV,
pubmed-author:YamamotoKaoruK,
pubmed-author:YamasakiYoshimitsuY
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1435-40
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pubmed:dateRevised |
2011-6-1
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pubmed:meshHeading |
pubmed-meshheading:16751181-Animals,
pubmed-meshheading:16751181-Homeodomain Proteins,
pubmed-meshheading:16751181-Metaplasia,
pubmed-meshheading:16751181-Mice,
pubmed-meshheading:16751181-Mice, Knockout,
pubmed-meshheading:16751181-Mice, Transgenic,
pubmed-meshheading:16751181-Pancreas,
pubmed-meshheading:16751181-STAT3 Transcription Factor,
pubmed-meshheading:16751181-Trans-Activators
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pubmed:year |
2006
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pubmed:articleTitle |
Persistent expression of PDX-1 in the pancreas causes acinar-to-ductal metaplasia through Stat3 activation.
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pubmed:affiliation |
Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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