Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2006-6-5
pubmed:abstractText
Tryptases secreted by tissue mast cells and basophils can enter the bloodstream. In human subjects tryptases are encoded by several genes and alleles, including alpha, beta, gamma, and delta. Common variations include complete absence of alpha genes. Until recently, alpha tryptase was considered to be the major tryptase secreted at baseline and in mastocytosis. However, lack of alpha tryptase genes has little effect on circulating tryptase levels, which are now thought mainly to consist of inactive pro-beta tryptase secreted constitutively rather than stored in granules with mature tryptases. Pro-beta tryptase levels thus might reflect total body mast cell content. In contrast, mature beta tryptase can increase transiently in severe systemic anaphylaxis and confirm the diagnosis. However, it might fail to increase in food anaphylaxis or might increase nonspecifically in samples acquired after death. Thus pro- and mature beta tryptase measurements are useful but associated with false-negative and false-positive results, which need to be considered in drawing clinical conclusions in cases of suspected anaphylaxis.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/16751005-10391906, http://linkedlifedata.com/resource/pubmed/commentcorrection/16751005-10843716, http://linkedlifedata.com/resource/pubmed/commentcorrection/16751005-11398082, http://linkedlifedata.com/resource/pubmed/commentcorrection/16751005-11823536, http://linkedlifedata.com/resource/pubmed/commentcorrection/16751005-12100045, http://linkedlifedata.com/resource/pubmed/commentcorrection/16751005-12194977, http://linkedlifedata.com/resource/pubmed/commentcorrection/16751005-12217407, http://linkedlifedata.com/resource/pubmed/commentcorrection/16751005-12391231, http://linkedlifedata.com/resource/pubmed/commentcorrection/16751005-12505465, http://linkedlifedata.com/resource/pubmed/commentcorrection/16751005-12759448, http://linkedlifedata.com/resource/pubmed/commentcorrection/16751005-14660743, http://linkedlifedata.com/resource/pubmed/commentcorrection/16751005-15025394, http://linkedlifedata.com/resource/pubmed/commentcorrection/16751005-15722637, http://linkedlifedata.com/resource/pubmed/commentcorrection/16751005-1629497, http://linkedlifedata.com/resource/pubmed/commentcorrection/16751005-2187193, http://linkedlifedata.com/resource/pubmed/commentcorrection/16751005-2468689, http://linkedlifedata.com/resource/pubmed/commentcorrection/16751005-3295549, http://linkedlifedata.com/resource/pubmed/commentcorrection/16751005-3549903, http://linkedlifedata.com/resource/pubmed/commentcorrection/16751005-7500033, http://linkedlifedata.com/resource/pubmed/commentcorrection/16751005-8144524, http://linkedlifedata.com/resource/pubmed/commentcorrection/16751005-8613553, http://linkedlifedata.com/resource/pubmed/commentcorrection/16751005-8810600, http://linkedlifedata.com/resource/pubmed/commentcorrection/16751005-9032489, http://linkedlifedata.com/resource/pubmed/commentcorrection/16751005-9485375, http://linkedlifedata.com/resource/pubmed/commentcorrection/16751005-9920877
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0091-6749
pubmed:author
pubmed:issnType
Print
pubmed:volume
117
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1411-4
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Tryptase genetics and anaphylaxis.
pubmed:affiliation
Cardiovascular Research Institute and Department of Medicine, University of California at San Francisco, CA 94121, USA. George.Caughey@ucsf.edu
pubmed:publicationType
Journal Article, Review, Research Support, N.I.H., Extramural