Linked Life Data

16750479

Source:http://linkedlifedata.com/resource/pubmed/id/16750479

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2006-6-5
pubmed:abstractText
Regional distribution of coenzyme Q10 and mitochondrial complex-1 activity were estimated in the brains of control-(C57BL/6), metallothionein knock out-, metallothionein transgenic-, and homozygous weaver mutant mice; and human dopaminergic (SK-N-SH) cells with a primary objective to determine the neuroprotective potential of coenzyme Q10 in Parkinson's disease. Complex-1 activity as well as coenzyme Q10 were significantly higher in the cerebral cortex as compared to the striatum in all the genotypes examined. Complex-1 activity and coenzyme Q10 were significantly reduced in weaver mutant mice and metallothionein knock out mice, but were significantly increased in metallothionein transgenic mice. The reduced complex-1 activity and 18F-DOPA uptake occurred concomitantly with negligible differences in the coenzyme Q10 between in the cerebral cortex and striatum of weaver mutant mice. Administration of coenzyme Q10 increased complex-1 activity and partially improved motoric performance in weaver mutant mice. Direct exposure of rotenone also reduced coenzyme Q10, complex-1 activity, and mitochondrial membrane potential in SK-N-SH cells. Rotenone-induced down-regulation of complex-1 activity was attenuated by coenzyme Q10 treatment, suggesting that complex-1 may be down regulated due to depletion of coenzyme Q10 in the brain. Therefore, metallothionein-induced coenzyme Q10 synthesis may provide neuroprotection by augmenting mitochondrial complex-1 activity in Parkinson's disease.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0361-9230
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
70
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
22-32
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:16750479-Analysis of Variance, pubmed-meshheading:16750479-Animals, pubmed-meshheading:16750479-Brain, pubmed-meshheading:16750479-Cell Line, Tumor, pubmed-meshheading:16750479-Chromatography, High Pressure Liquid, pubmed-meshheading:16750479-Coenzymes, pubmed-meshheading:16750479-Dihydroxyphenylalanine, pubmed-meshheading:16750479-Disease Models, Animal, pubmed-meshheading:16750479-Electron Transport Complex I, pubmed-meshheading:16750479-Fluorine Radioisotopes, pubmed-meshheading:16750479-Humans, pubmed-meshheading:16750479-Male, pubmed-meshheading:16750479-Metallothionein, pubmed-meshheading:16750479-Mice, pubmed-meshheading:16750479-Mice, Inbred C57BL, pubmed-meshheading:16750479-Mice, Neurologic Mutants, pubmed-meshheading:16750479-Mice, Transgenic, pubmed-meshheading:16750479-Neuroblastoma, pubmed-meshheading:16750479-Neuroprotective Agents, pubmed-meshheading:16750479-Parkinson Disease, pubmed-meshheading:16750479-Positron-Emission Tomography, pubmed-meshheading:16750479-Statistics as Topic, pubmed-meshheading:16750479-Tissue Distribution, pubmed-meshheading:16750479-Ubiquinone
pubmed:year
2006
pubmed:articleTitle
Complex-1 activity and 18F-DOPA uptake in genetically engineered mouse model of Parkinson's disease and the neuroprotective role of coenzyme Q10.
pubmed:affiliation
Department of Pharmacology, University of North Dakota School of Medicine and Health Sciences, 501 North Columbia Road, Grand Forks, ND 58203, United States.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, N.I.H., Extramural