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rdf:type |
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lifeskim:mentions |
umls-concept:C0012655,
umls-concept:C0013227,
umls-concept:C0014442,
umls-concept:C0017262,
umls-concept:C0020205,
umls-concept:C0023693,
umls-concept:C0024554,
umls-concept:C0025920,
umls-concept:C0026809,
umls-concept:C0031412,
umls-concept:C0033414,
umls-concept:C0185117,
umls-concept:C0205054,
umls-concept:C0205263,
umls-concept:C0439539,
umls-concept:C0443199,
umls-concept:C1707520,
umls-concept:C2911684
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pubmed:issue |
5
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pubmed:dateCreated |
1991-6-19
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pubmed:abstractText |
Higher body and carcass (body - liver) weights in sodium phenobarbital (PB) treated mice correlate with formation of multiple hepatocellular adenomas in yellow Avy/A and agouti A/a (C3H x VY) F1 hybrid male mice. To assess differences in PB induction of hepatic drug metabolizing enzymes, yellow Avy/A (C3H x VY) F1 hybrid male mice were fed 0.05% sodium PB in NIH-31 diet for 7 months. Livers from the heaviest and lightest mice in the untreated and PB groups were assayed. Total cytochrome P450 content, cytochrome P450IA-selective 7-ethoxyresorufin-O-deethylase and P450IIIA-selective testosterone-6 beta-hydroxylase activities were preferentially induced in the light mice. In contrast, P450IIB-selective 7-pentoxyresorufin-O-dealkylase activity was increased only 3-fold by PB in the light mice but 6-fold in the heavy mice. Testosterone UDP-glucuronyltransferase and gamma-glutamyltranspeptidase activities were induced in the light mice but not in the heavy mice. Glutathione-S-transferase N1:1-dependent activity was induced preferentially in the heavy mice. Significant differences also occurred in constitutive expression of P450IIIA-selective testosterone-6 beta-hydroxylase, P450IA-selective 7-ethoxyresorufin-O-deethylase and testosterone UDP-glucuronyltransferase activities between the untreated weight groups. Thus, expression of constitutive and PB-inducible forms of hepatic drug metabolizing enzymes differs between heavy and light Avy/A (C3H x VY) F1 hybrid subpopulations. This suggests that differential susceptibility to PB promotion of hepatocellular adenomas among genetically identical mice is accompanied by differences in the regulation of gene expression.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Aryl Hydrocarbon Hydroxylases,
http://linkedlifedata.com/resource/pubmed/chemical/Carcinogens,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 CYP1A1,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 CYP2B1,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 Enzyme System,
http://linkedlifedata.com/resource/pubmed/chemical/Glucuronosyltransferase,
http://linkedlifedata.com/resource/pubmed/chemical/Glutathione Transferase,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Mixed Function Oxygenases,
http://linkedlifedata.com/resource/pubmed/chemical/Oxidoreductases,
http://linkedlifedata.com/resource/pubmed/chemical/Phenobarbital,
http://linkedlifedata.com/resource/pubmed/chemical/Steroid Hydroxylases,
http://linkedlifedata.com/resource/pubmed/chemical/gamma-Glutamyltransferase,
http://linkedlifedata.com/resource/pubmed/chemical/testosterone 7-alpha-hydroxylase...
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0143-3334
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
911-5
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1674234-Adenoma,
pubmed-meshheading:1674234-Animals,
pubmed-meshheading:1674234-Aryl Hydrocarbon Hydroxylases,
pubmed-meshheading:1674234-Blotting, Western,
pubmed-meshheading:1674234-Body Weight,
pubmed-meshheading:1674234-Carcinogens,
pubmed-meshheading:1674234-Cytochrome P-450 CYP1A1,
pubmed-meshheading:1674234-Cytochrome P-450 CYP2B1,
pubmed-meshheading:1674234-Cytochrome P-450 Enzyme System,
pubmed-meshheading:1674234-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:1674234-Glucuronosyltransferase,
pubmed-meshheading:1674234-Glutathione Transferase,
pubmed-meshheading:1674234-Isoenzymes,
pubmed-meshheading:1674234-Liver Neoplasms,
pubmed-meshheading:1674234-Male,
pubmed-meshheading:1674234-Mice,
pubmed-meshheading:1674234-Microsomes, Liver,
pubmed-meshheading:1674234-Mixed Function Oxygenases,
pubmed-meshheading:1674234-Organ Size,
pubmed-meshheading:1674234-Oxidoreductases,
pubmed-meshheading:1674234-Phenobarbital,
pubmed-meshheading:1674234-Steroid Hydroxylases,
pubmed-meshheading:1674234-gamma-Glutamyltransferase
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pubmed:year |
1991
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pubmed:articleTitle |
Susceptibility to phenobarbital promotion of hepatotumorigenesis: correlation with differential expression and induction of hepatic drug metabolizing enzymes in heavy and light male (C3H x VY) F1 hybrid mice.
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pubmed:affiliation |
Division of Comparative Toxicology, National Center for Toxicological Research, Jefferson, AR 72079.
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pubmed:publicationType |
Journal Article
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