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rdf:type |
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|
lifeskim:mentions |
|
|
pubmed:issue |
5
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|
pubmed:dateCreated |
2006-6-19
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|
pubmed:abstractText |
The role of the delta-opioid receptor (OPRD1) in methamphetamine (MAP) addiction was investigated using association analysis between OPRD1 gene polymorphisms and MAP dependence/psychosis. DNA samples from Japanese patients with MAP dependence/psychosis were analyzed to find polymorphisms in OPRD1 gene exons and exon-intron boundaries. One novel single nucleotide polymorphism (SNP) in intron 1 and two SNPs in exon 3 were identified. The two SNPs in exon 3 were in linkage disequilibrium. No significant difference was observed in either genotypic or allelic frequencies of these SNPs between controls (n = 260) and MAP dependent/psychotic patients (n = 170). Global analyses using the three SNPs and subcategory analyses on clinical parameters also showed no significant differences. These results suggest that the OPRD1 gene variants may not be a factor in vulnerability to MAP dependence/psychosis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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|
pubmed:status |
MEDLINE
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pubmed:month |
Jul
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|
pubmed:issn |
1552-4841
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|
pubmed:author |
pubmed-author:HaranoMutsuoM,
pubmed-author:HataHarumiH,
pubmed-author:IdeSoichiroS,
pubmed-author:IkedaKazutakaK,
pubmed-author:InadaToshiyaT,
pubmed-author:ItokawaMasanariM,
pubmed-author:IwataNakaoN,
pubmed-author:IyoMasaomiM,
pubmed-author:KobayashiHideakiH,
pubmed-author:KomiyamaTokutaroT,
pubmed-author:NakaMakiM,
pubmed-author:NumachiYohtaroY,
pubmed-author:OzakiNorioN,
pubmed-author:SekineYoshimotoY,
pubmed-author:SoraIchiroI,
pubmed-author:UjikeHiroshiH,
pubmed-author:YamadaMitsuhikoM
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pubmed:copyrightInfo |
(c) 2006 Wiley-Liss, Inc.
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pubmed:issnType |
Print
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pubmed:day |
5
|
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pubmed:volume |
141B
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
482-6
|
|
pubmed:dateRevised |
2008-5-21
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|
pubmed:meshHeading |
pubmed-meshheading:16741914-Adult,
pubmed-meshheading:16741914-Alleles,
pubmed-meshheading:16741914-Female,
pubmed-meshheading:16741914-Gene Frequency,
pubmed-meshheading:16741914-Genetic Predisposition to Disease,
pubmed-meshheading:16741914-Genotype,
pubmed-meshheading:16741914-Humans,
pubmed-meshheading:16741914-Japan,
pubmed-meshheading:16741914-Linkage Disequilibrium,
pubmed-meshheading:16741914-Male,
pubmed-meshheading:16741914-Methamphetamine,
pubmed-meshheading:16741914-Middle Aged,
pubmed-meshheading:16741914-Polymorphism, Single Nucleotide,
pubmed-meshheading:16741914-Psychoses, Substance-Induced,
pubmed-meshheading:16741914-Receptors, Opioid, delta
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pubmed:year |
2006
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pubmed:articleTitle |
Association analysis of delta-opioid receptor gene polymorphisms in methamphetamine dependence/psychosis.
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pubmed:affiliation |
Department of Psychobiology, Tohoku University Graduate School of Medicine, Sendai, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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