16741886

Source:http://linkedlifedata.com/resource/pubmed/id/16741886

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0007634, umls-concept:C0021311, umls-concept:C0023395, umls-concept:C0024109, umls-concept:C0038027, umls-concept:C0051962, umls-concept:C0221099, umls-concept:C0443307, umls-concept:C1320928, umls-concept:C1334145, umls-concept:C1549439, umls-concept:C2347958
pubmed:issue	1
pubmed:dateCreated	2006-6-2
pubmed:abstractText	Bacillus anthracis secretes 2 toxins: lethal toxin (LT) and edema toxin (ET). We investigated their role in the physiopathologic mechanisms of inhalational anthrax by evaluating murine lung dendritic cell (LDC) functions after infection with B. anthracis strains secreting LT, ET, or both or with a nontoxinogenic strain. Three lung cell populations gated on CD11c/CD11b expression were obtained after lung digestion: (1) CD11c(high)/CD11b(low) (alveolar macrophages), (2) CD11c(intermediate (int))/CD11b(int) (LDCs), and (3) CD11c(low)/CD11b(high) (interstitial macrophages or monocytes). After infection with LT-secreting strains, a decrease in costimulatory molecule expression on LDCs was observed. All CD11c+ cells infected with a nontoxinogenic strain secreted tumor necrosis factor (TNF)- alpha , interleukin (IL)-10, and IL-6. LT-secreting strains inhibited overall cytokine secretion, whereas the ET-secreting strain inhibited only TNF- alpha secretion and increased IL-6 secretion. Similar results were obtained after preincubation with purified toxins. Our results suggest that anthrax toxins secreted during infection impair LDC function and suppress the innate immune response.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0413675
pubmed:citationSubset	AIM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Bacterial, http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD11c, http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Toxins, http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-10, http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6, http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha, http://linkedlifedata.com/resource/pubmed/chemical/anthrax toxin
pubmed:status	MEDLINE
pubmed:month	Jul
pubmed:issn	0022-1899
pubmed:author	pubmed-author:CleretAurelieA, pubmed-author:MathieuJacquesJ, pubmed-author:Quesnel-HellmannAnneA, pubmed-author:TournierJean-NicolasJN, pubmed-author:VidalDominiqueD
pubmed:issnType	Print
pubmed:day	1
pubmed:volume	194
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	86-94
pubmed:dateRevised	2006-11-15
pubmed:meshHeading	pubmed-meshheading:16741886-Animals, pubmed-meshheading:16741886-Antigens, Bacterial, pubmed-meshheading:16741886-Antigens, CD11c, pubmed-meshheading:16741886-Bacillus anthracis, pubmed-meshheading:16741886-Bacterial Toxins, pubmed-meshheading:16741886-Cells, Cultured, pubmed-meshheading:16741886-Dendritic Cells, pubmed-meshheading:16741886-Gene Expression, pubmed-meshheading:16741886-Interleukin-10, pubmed-meshheading:16741886-Interleukin-6, pubmed-meshheading:16741886-Lung, pubmed-meshheading:16741886-Macrophages, Alveolar, pubmed-meshheading:16741886-Male, pubmed-meshheading:16741886-Mice, pubmed-meshheading:16741886-Mice, Inbred BALB C, pubmed-meshheading:16741886-Monocytes, pubmed-meshheading:16741886-Phagocytosis, pubmed-meshheading:16741886-Spores, Bacterial, pubmed-meshheading:16741886-Tumor Necrosis Factor-alpha
pubmed:year	2006
pubmed:articleTitle	Resident CD11c+ lung cells are impaired by anthrax toxins after spore infection.
pubmed:affiliation	Unité d'Immunobiologie, Département de Biologie des Agents Transmissibles, Centre de Recherche du Service de Santé des Armées, La Tronche, France.
pubmed:publicationType	Journal Article, Comparative Study, Research Support, Non-U.S. Gov't