Linked Life Data

16741522

Source:http://linkedlifedata.com/resource/pubmed/id/16741522

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2006-8-23
pubmed:abstractText
Biliary cystic tumors, which are also called biliary cystadenoma and cystadenocarcinoma, are thought to be a heterogeneous disease entity, and some of them are known to show a luminal communication to the bile duct. In this study, we examined the clinicopathological features of nine cases of biliary cystic tumors with bile duct communication. They were composed of five males and four females with an average age of 67 years (52-84 years). They were multilocular (eight cases) or unilocular (one case), and all cases contained mucinous fluid. A direct luminal communication with the bile ducts was identified in five cases on preoperative or intraoperative cholangiographies. Biliary cystic tumors examined in this study were histologically adenoma (one case), adenocarcinoma in situ (six cases), and adenocarcinoma associated with microinvasive mucinous carcinoma (two cases). One case of adenocarcinoma in situ also had the adenoma component (adenocarcinoma in adenoma). Dysplastic mucinous epithelium proliferated in flat, micropapillary and papillary fashions within the intracystic spaces. Intraepithelial neoplasm was observed within non-dilated adjacent bile ducts, suggesting a direct luminal communication between the cystic tumors and the bile duct. Ovarian-like stroma was not observed in their walls in any cases. Immunohistochemically, seven cases expressed MUC1 or MUC2 in the neoplastic biliary epithelium. All cases except one were alive without any evidences of tumor recurrence after total excision (3-156 months after surgery). These clinicopathological features resembled those of intraductal papillary neoplasm of the bile duct, which had been reported as a biliary counterpart of pancreatic intraductal papillary mucinous neoplasm. In conclusion, biliary cystic tumors with bile duct communication could be regarded as intraductal papillary neoplasm with a prominent cystic dilatation of the bile duct and mucin retention, rather than true biliary cystic neoplasms.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0893-3952
pubmed:author
pubmed:copyrightInfo
Published online 2 June 2006.
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1243-54
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:16741522-Adenocarcinoma, Papillary, pubmed-meshheading:16741522-Aged, pubmed-meshheading:16741522-Aged, 80 and over, pubmed-meshheading:16741522-Bile Duct Neoplasms, pubmed-meshheading:16741522-Bile Ducts, Intrahepatic, pubmed-meshheading:16741522-Carcinoma in Situ, pubmed-meshheading:16741522-Cholangiocarcinoma, pubmed-meshheading:16741522-Cystadenocarcinoma, pubmed-meshheading:16741522-Cystadenoma, pubmed-meshheading:16741522-Disease-Free Survival, pubmed-meshheading:16741522-Female, pubmed-meshheading:16741522-Fluorescent Antibody Technique, Indirect, pubmed-meshheading:16741522-Homeodomain Proteins, pubmed-meshheading:16741522-Humans, pubmed-meshheading:16741522-Immunoenzyme Techniques, pubmed-meshheading:16741522-Male, pubmed-meshheading:16741522-Middle Aged, pubmed-meshheading:16741522-Mucin-1, pubmed-meshheading:16741522-Mucin-2, pubmed-meshheading:16741522-Mucins, pubmed-meshheading:16741522-Trans-Activators, pubmed-meshheading:16741522-Tumor Markers, Biological
pubmed:year
2006
pubmed:articleTitle
Biliary cystic tumors with bile duct communication: a cystic variant of intraductal papillary neoplasm of the bile duct.
pubmed:affiliation
Department of Human Pathology, Kanazawa University Graduate School of Medicine, Takaramachi, Kanazawa, Japan.
pubmed:publicationType
Journal Article