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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2006-7-19
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pubmed:abstractText |
IL-12 is a Th1-inducing cytokine and known to be induced by some food factors. This function of such foods is expected to be applied for antiallergic materials. However, the influence of IL-12 on the immune responses has not been fully investigated. Oral tolerance is an immunologically unresponsive state induced by orally administered food antigens. Although a failure in the induction of oral tolerance would result in food allergy, the mechanisms for the induction and abrogation of oral tolerance have not been clarified. IL-12 induced by food factors may also affect the induction of oral tolerance. In this study we examined the effect of the oral administration of IL-12 on the induction and maintenance of oral tolerance.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1018-2438
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2006 S. Karger AG, Basel.
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pubmed:issnType |
Print
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pubmed:volume |
140
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
306-14
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16741366-Administration, Oral,
pubmed-meshheading:16741366-Animals,
pubmed-meshheading:16741366-Antibody Formation,
pubmed-meshheading:16741366-Clonal Anergy,
pubmed-meshheading:16741366-Coculture Techniques,
pubmed-meshheading:16741366-Dietary Proteins,
pubmed-meshheading:16741366-Epitopes, B-Lymphocyte,
pubmed-meshheading:16741366-Female,
pubmed-meshheading:16741366-Immune Tolerance,
pubmed-meshheading:16741366-Immunoglobulin G,
pubmed-meshheading:16741366-Interleukin-12,
pubmed-meshheading:16741366-Lactoglobulins,
pubmed-meshheading:16741366-Lymph Nodes,
pubmed-meshheading:16741366-Lymphocyte Activation,
pubmed-meshheading:16741366-Mice,
pubmed-meshheading:16741366-Mice, Inbred BALB C,
pubmed-meshheading:16741366-Spleen,
pubmed-meshheading:16741366-T-Lymphocytes,
pubmed-meshheading:16741366-Vaccination
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pubmed:year |
2006
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pubmed:articleTitle |
Oral administration of IL-12 abrogates the induction but not the maintenance of oral tolerance.
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pubmed:affiliation |
Department of Applied Biological Science, Tokyo University of Agriculture and Technology, Tokyo, Japan. tyoshi@cc.tuat.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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