Source:http://linkedlifedata.com/resource/pubmed/id/16741267
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2006-6-2
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| pubmed:abstractText |
A polymorphism in the promoter region of uncoupling protein 2 gene -866G/A has been associated with its expression levels in adipose tissue, the risk of obesity, and metabolic abnormalities. Our purpose was to examine the associations of -866G/A with body fat and the risk of metabolic syndrome in a random sample of 4018 Asians (1858 men and 2160 women) from three ethnic groups (Chinese, Malay, and Indian). The minor allele frequency of -866G/A polymorphism in South Asians was similar to that in whites. After adjustment for covariates including age, cigarette smoking, and physical activity, the -866A/A genotype was associated with higher waist-to-hip ratio as compared with the wild-type genotype in Chinese and Indian men (p = 0.018 and p = 0.046, respectively). Moreover, Indian men with -866A/A genotype had a significantly increased risk of metabolic syndrome as compared with those homozygous for the wild-type (odds ratio, 2.66; 95% confidence interval, 1.21 to 5.88; p = 0.015). Such a risk was mainly caused by the excess presence of hypertriglyceridemia and central obesity. Our findings indicate that the uncoupling protein 2 gene -866G/A polymorphism may increase the risks of central obesity and metabolic syndrome, with greater effects on Asian men.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
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| pubmed:issn |
1930-7381
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
14
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
656-61
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| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:16741267-Adiposity,
pubmed-meshheading:16741267-Adult,
pubmed-meshheading:16741267-Asia,
pubmed-meshheading:16741267-Asian Continental Ancestry Group,
pubmed-meshheading:16741267-Blood Pressure,
pubmed-meshheading:16741267-Body Mass Index,
pubmed-meshheading:16741267-Diabetes Mellitus,
pubmed-meshheading:16741267-Female,
pubmed-meshheading:16741267-Humans,
pubmed-meshheading:16741267-India,
pubmed-meshheading:16741267-Intra-Abdominal Fat,
pubmed-meshheading:16741267-Ion Channels,
pubmed-meshheading:16741267-Malaysia,
pubmed-meshheading:16741267-Male,
pubmed-meshheading:16741267-Metabolic Syndrome X,
pubmed-meshheading:16741267-Middle Aged,
pubmed-meshheading:16741267-Mitochondrial Proteins,
pubmed-meshheading:16741267-Polymorphism, Genetic,
pubmed-meshheading:16741267-Polymorphism, Single Nucleotide,
pubmed-meshheading:16741267-Promoter Regions, Genetic,
pubmed-meshheading:16741267-Waist-Hip Ratio
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| pubmed:year |
2006
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| pubmed:articleTitle |
Uncoupling protein 2 promoter polymorphism -866G/A, central adiposity, and metabolic syndrome in Asians.
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| pubmed:affiliation |
Nutrition and Genomics Laboratory, US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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