Linked Life Data

1674118

Source:http://linkedlifedata.com/resource/pubmed/id/1674118

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1991-6-7
pubmed:abstractText
We performed linkage analyses of juvenile parkinsonism with autosomal recessive inheritance (AR-JP) to chromosome 11p15.5 locus including tyrosine hydroxylase (TH), Harvey-ras-1 (HRAS), and insulin (INS) genes by analyzing genomic DNA from 28 members of seven Japanese AR-JP families containing 10 affected individuals. We used the methods of pairwise linkage analysis (LIPED) and multipoint linkage analysis (LINKAGE) for genetic linkage to the chromosome 11p15.5 markers and detected recombination events between AR-JP locus and TH gene. Multipoint linkage analysis excluded the linkage in the interval between TH and HRAS, as well as 11 cMo distal to TH and 8.5 cMo distal to HRAS, a total of approximately 23 cMo on chromosome 11p.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0028-3878
pubmed:author
pubmed:issnType
Print
pubmed:volume
41
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
719-22
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Linkage analysis of juvenile parkinsonism to tyrosine hydroxylase gene locus on chromosome 11.
pubmed:affiliation
Department of Neurology, Niigata University, Japan.
pubmed:publicationType
Journal Article, Case Reports, Research Support, Non-U.S. Gov't