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| pubmed-article:16740477 | lifeskim:mentions | umls-concept:C0058836 | lld:lifeskim |
| pubmed-article:16740477 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:16740477 | lifeskim:mentions | umls-concept:C0699900 | lld:lifeskim |
| pubmed-article:16740477 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:16740477 | lifeskim:mentions | umls-concept:C0243125 | lld:lifeskim |
| pubmed-article:16740477 | lifeskim:mentions | umls-concept:C0162610 | lld:lifeskim |
| pubmed-article:16740477 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:16740477 | lifeskim:mentions | umls-concept:C1516044 | lld:lifeskim |
| pubmed-article:16740477 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:16740477 | pubmed:dateCreated | 2006-6-2 | lld:pubmed |
| pubmed-article:16740477 | pubmed:abstractText | Dynamins are large GTPases that act in multiple vesicular trafficking events. We identified 14 loss-of-function alleles of the C. elegans dynamin gene, dyn-1, that are defective in the removal of apoptotic cells. dyn-1 functions in engulfing cells to control the internalization and degradation of apoptotic cells. dyn-1 acts in the genetic pathway composed of ced-7 (ABC transporter), ced-1 (phagocytic receptor), and ced-6 (CED-1's adaptor). DYN-1 transiently accumulates to the surface of pseudopods in a manner dependent on ced-1, ced-6, and ced-7, but not on ced-5, ced-10, or ced-12. Abnormal vesicle structures accumulate in engulfing cells upon dyn-1 inactivation. dyn-1 and ced-1 mutations block the recruitment of intracellular vesicles to pseudopods and phagosomes. We propose that DYN-1 mediates the signaling of the CED-1 pathway by organizing an intracellular vesicle pool and promoting vesicle delivery to phagocytic cups and phagosomes to support pseudopod extension and apoptotic cell degradation. | lld:pubmed |
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| pubmed-article:16740477 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16740477 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:16740477 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16740477 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16740477 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:16740477 | pubmed:issn | 1534-5807 | lld:pubmed |
| pubmed-article:16740477 | pubmed:author | pubmed-author:YuXiaomengX | lld:pubmed |
| pubmed-article:16740477 | pubmed:author | pubmed-author:ZhouZhengZ | lld:pubmed |
| pubmed-article:16740477 | pubmed:author | pubmed-author:LuNanN | lld:pubmed |
| pubmed-article:16740477 | pubmed:author | pubmed-author:OderaSampeter... | lld:pubmed |
| pubmed-article:16740477 | pubmed:author | pubmed-author:ChuangChin-Hu... | lld:pubmed |
| pubmed-article:16740477 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16740477 | pubmed:volume | 10 | lld:pubmed |
| pubmed-article:16740477 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16740477 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16740477 | pubmed:pagination | 743-57 | lld:pubmed |
| pubmed-article:16740477 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:16740477 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16740477 | pubmed:articleTitle | C. elegans Dynamin mediates the signaling of phagocytic receptor CED-1 for the engulfment and degradation of apoptotic cells. | lld:pubmed |
| pubmed-article:16740477 | pubmed:affiliation | Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA. | lld:pubmed |
| pubmed-article:16740477 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16740477 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:16740477 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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