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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2006-6-2
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pubmed:abstractText |
Dynamins are large GTPases that act in multiple vesicular trafficking events. We identified 14 loss-of-function alleles of the C. elegans dynamin gene, dyn-1, that are defective in the removal of apoptotic cells. dyn-1 functions in engulfing cells to control the internalization and degradation of apoptotic cells. dyn-1 acts in the genetic pathway composed of ced-7 (ABC transporter), ced-1 (phagocytic receptor), and ced-6 (CED-1's adaptor). DYN-1 transiently accumulates to the surface of pseudopods in a manner dependent on ced-1, ced-6, and ced-7, but not on ced-5, ced-10, or ced-12. Abnormal vesicle structures accumulate in engulfing cells upon dyn-1 inactivation. dyn-1 and ced-1 mutations block the recruitment of intracellular vesicles to pseudopods and phagosomes. We propose that DYN-1 mediates the signaling of the CED-1 pathway by organizing an intracellular vesicle pool and promoting vesicle delivery to phagocytic cups and phagosomes to support pseudopod extension and apoptotic cell degradation.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1534-5807
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
743-57
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:16740477-Alleles,
pubmed-meshheading:16740477-Amino Acid Sequence,
pubmed-meshheading:16740477-Animals,
pubmed-meshheading:16740477-Apoptosis,
pubmed-meshheading:16740477-Caenorhabditis elegans,
pubmed-meshheading:16740477-Caenorhabditis elegans Proteins,
pubmed-meshheading:16740477-Conserved Sequence,
pubmed-meshheading:16740477-Dynamins,
pubmed-meshheading:16740477-Embryo, Nonmammalian,
pubmed-meshheading:16740477-Helminth Proteins,
pubmed-meshheading:16740477-Membrane Proteins,
pubmed-meshheading:16740477-Models, Biological,
pubmed-meshheading:16740477-Molecular Sequence Data,
pubmed-meshheading:16740477-Mutation,
pubmed-meshheading:16740477-Phagocytosis,
pubmed-meshheading:16740477-Protein Structure, Tertiary,
pubmed-meshheading:16740477-Sequence Homology, Amino Acid,
pubmed-meshheading:16740477-Signal Transduction
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pubmed:year |
2006
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pubmed:articleTitle |
C. elegans Dynamin mediates the signaling of phagocytic receptor CED-1 for the engulfment and degradation of apoptotic cells.
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pubmed:affiliation |
Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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