Linked Life Data

16739141

Source:http://linkedlifedata.com/resource/pubmed/id/16739141

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2006-11-27
pubmed:databankReference
pubmed:abstractText
In mammals, thyroid hormone (TH) signaling is essential for metabolic control, differentiation and homeostasis. These hormones are also involved in the regulation of metamorphosis in amphibians and lampreys and a role in basal chordates has been suggested. Increasing evidence supports TH-related function not only in basal chordates such as urochordates and cephalochordates but also in other invertebrate groups. However, the regulatory mechanisms underlying TH function including the mechanisms of endogenous synthesis of hormones in these groups are essentially unknown. Our data provide evidence for endogenous TH synthesis in the sea hare Aplysia californica and the sea urchin Lytechinus variegatus based on thin layer chromatography. Pharmacological experiments show that these hormones accelerate development to metamorphosis and specifically affect the formation of juvenile skeletal structures in the sea urchin. Furthermore, we identified two new peroxidase genes (LvTPO from L. variegatus and AcaTPO from A. californica) showing high sequence similarity with peroxidasin and thyroid peroxidases (the critical TH synthesis enzymes found in all vertebrates). Spatial and temporal expression patterns of these transcripts suggest a role of LvTPO and AcaTPO in a variety of processes such as development to metamorphosis and the regulation of the animal's energetics. We discuss our new findings in the context of evolution of TH synthesis and TH signaling in non-chordate animals.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1552-5007
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
306
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
551-66
pubmed:dateRevised
2009-10-5
pubmed:meshHeading
pubmed-meshheading:16739141-Animals, pubmed-meshheading:16739141-Aplysia, pubmed-meshheading:16739141-Base Sequence, pubmed-meshheading:16739141-Bayes Theorem, pubmed-meshheading:16739141-Chromatography, Thin Layer, pubmed-meshheading:16739141-Cloning, Molecular, pubmed-meshheading:16739141-DNA Primers, pubmed-meshheading:16739141-Extracellular Matrix Proteins, pubmed-meshheading:16739141-In Situ Hybridization, pubmed-meshheading:16739141-Iodide Peroxidase, pubmed-meshheading:16739141-Iodine, pubmed-meshheading:16739141-Larva, pubmed-meshheading:16739141-Likelihood Functions, pubmed-meshheading:16739141-Metamorphosis, Biological, pubmed-meshheading:16739141-Models, Genetic, pubmed-meshheading:16739141-Molecular Sequence Data, pubmed-meshheading:16739141-Morphogenesis, pubmed-meshheading:16739141-Peroxidase, pubmed-meshheading:16739141-Phylogeny, pubmed-meshheading:16739141-Sea Urchins, pubmed-meshheading:16739141-Sequence Analysis, DNA, pubmed-meshheading:16739141-Thiourea, pubmed-meshheading:16739141-Thyroid Hormones
pubmed:year
2006
pubmed:articleTitle
Thyroid hormone metabolism and peroxidase function in two non-chordate animals.
pubmed:affiliation
The Whitney Laboratory for Marine Bioscience, University of Florida, St Augustine, FL 32080, USA. aheyland@ufl.edu
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural