Source:http://linkedlifedata.com/resource/pubmed/id/16739030
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2006-6-1
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| pubmed:abstractText |
The aim of the present study was to evaluate the spectrum of late effects in a large cohort of pediatric patients with low-grade gliomas (WHO grade I and II) during an observation period of 20 years. Eighty-seven patients with low-grade gliomas grouped according to tumor location (cerebellum: n=28; cerebral hemispheres: n=21; central midline: n=15; brainstem: n=12; tectum: n=5; other locations: n=6) were evaluated for tumor- and/or treatment-related late effects by analysis of medical and computer records, and personal interviews. Seventy patients underwent neurosurgery, 29 patients received additional radiotherapy and 20 additional chemotherapy. Median follow-up of survivors is 96 months with an overall survival of 79% (cerebellum: 89%; cerebral hemispheres: 95%; central midline: 80%; brainstem: 25%; tectum: 100%; other locations: 66%). Chronic medical problems (mild ataxia to multiple severe neuroendocrine deficits) are observed in 100% of patients with brainstem/central midline tumors and in 40-50% of patients with low-grade gliomas of other locations. Endocrine deficiencies were observed in 15/17 (88%) of long-term survivors who received radiotherapy. In contrast, none of the patients who underwent surgery only had endocrine deficiencies. Seven long-term survivors (10.1%) are severely disabled with permanent need of medical help. Tumor- and treatment-related late effects are common in patients with low-grade gliomas with the most severe occurring in patients with brainstem or central midline tumors. As long-term survival is excellent in patients with low-grade gliomas except for tumors located in the brainstem, future treatment studies should focus on avoiding long-term late effects.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jun
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| pubmed:issn |
0167-594X
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| pubmed:author |
pubmed-author:BeneschMartinM,
pubmed-author:DornbuschHans JürgenHJ,
pubmed-author:EderHans-GeorgHG,
pubmed-author:LacknerHerwigH,
pubmed-author:MoserAndreaA,
pubmed-author:SchwingerWolfgangW,
pubmed-author:SovinzPetraP,
pubmed-author:SuppanElisabethE,
pubmed-author:Triebl-RothKarinK,
pubmed-author:UrbanChristianC
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| pubmed:issnType |
Print
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| pubmed:volume |
78
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
199-205
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| pubmed:meshHeading |
pubmed-meshheading:16739030-Adolescent,
pubmed-meshheading:16739030-Adult,
pubmed-meshheading:16739030-Antineoplastic Agents,
pubmed-meshheading:16739030-Austria,
pubmed-meshheading:16739030-Brain Neoplasms,
pubmed-meshheading:16739030-Child,
pubmed-meshheading:16739030-Child, Preschool,
pubmed-meshheading:16739030-Cohort Studies,
pubmed-meshheading:16739030-Combined Modality Therapy,
pubmed-meshheading:16739030-Disease-Free Survival,
pubmed-meshheading:16739030-Endocrine System Diseases,
pubmed-meshheading:16739030-Female,
pubmed-meshheading:16739030-Follow-Up Studies,
pubmed-meshheading:16739030-Glioma,
pubmed-meshheading:16739030-Hearing Disorders,
pubmed-meshheading:16739030-Humans,
pubmed-meshheading:16739030-Infant,
pubmed-meshheading:16739030-Male,
pubmed-meshheading:16739030-Nervous System Diseases,
pubmed-meshheading:16739030-Radiation Injuries,
pubmed-meshheading:16739030-Retrospective Studies,
pubmed-meshheading:16739030-Survivors,
pubmed-meshheading:16739030-Vision Disorders
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| pubmed:year |
2006
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| pubmed:articleTitle |
Late sequela after treatment of childhood low-grade gliomas: a retrospective analysis of 69 long-term survivors treated between 1983 and 2003.
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| pubmed:affiliation |
Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Graz, Austria. martin.benesch@klinikum-graz.at
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| pubmed:publicationType |
Journal Article
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