Linked Life Data

16737746

Source:http://linkedlifedata.com/resource/pubmed/id/16737746

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pubmed-article:16737746pubmed:abstractTextThe Ras-MAPK signal transduction pathway controls multiple developmental events and is involved in the processing of olfactory information in the free living nematode Caenorhabditis elegans. We have studied the Ras-MAPK pathway in the plant parasitic nematode Meloidogyne artiellia. The genes Mt-let-60, Mt-lin-45, Mt-mek-2 and Mt-mpk-1 have been isolated and sequenced. Each of them shows a high level of sequence similarity to its presumed ortholog in C. elegans and key functional domains are structurally conserved. Furthermore, we show that the M. artiellia recombinant MEK-2 protein can phosphorylate and activate the M. artiellia recombinant MPK-1 and the recombinant MEK-2 itself can be phosphorylated and activated by immunoprecipitated mammalian Raf. Surprisingly, the Mt-lin-45 message is not detectable in freshly emerged juveniles or in male specimens, suggesting that it may be quickly degraded in these life stages.lld:pubmed
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pubmed-article:16737746pubmed:articleTitleThe expression of the homologue of the Caenorhabditis elegans lin-45 raf is regulated in the motile stages of the plant parasitic nematode Meloidogyne artiellia.lld:pubmed
pubmed-article:16737746pubmed:affiliationDipartimento di Biochimica e Biologia Molecolare, Via Orabona 4, 70126 Bari, Italy.lld:pubmed
pubmed-article:16737746pubmed:publicationTypeJournal Articlelld:pubmed
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