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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0032098,
umls-concept:C0162610,
umls-concept:C0185117,
umls-concept:C0521066,
umls-concept:C0851285,
umls-concept:C1010159,
umls-concept:C1306673,
umls-concept:C1334043,
umls-concept:C1704319,
umls-concept:C1979933,
umls-concept:C2911684
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pubmed:issue |
1
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pubmed:dateCreated |
2006-7-17
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pubmed:databankReference |
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AAA18956,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AAB25349,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AAF60779,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AAL48618,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AAM12630,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AJ514924,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AJ514925,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AJ514926,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AJ514927,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AJ514928,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/BAA01733,
http://linkedlifedata.com/resource/pubmed/xref/RefSeq/NP_002515,
http://linkedlifedata.com/resource/pubmed/xref/RefSeq/NP_002746,
http://linkedlifedata.com/resource/pubmed/xref/RefSeq/NP_004976,
http://linkedlifedata.com/resource/pubmed/xref/RefSeq/NP_036771,
http://linkedlifedata.com/resource/pubmed/xref/RefSeq/NP_059043,
http://linkedlifedata.com/resource/pubmed/xref/RefSeq/NP_113831,
http://linkedlifedata.com/resource/pubmed/xref/RefSeq/NP_203524,
http://linkedlifedata.com/resource/pubmed/xref/RefSeq/NP_476699
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pubmed:abstractText |
The Ras-MAPK signal transduction pathway controls multiple developmental events and is involved in the processing of olfactory information in the free living nematode Caenorhabditis elegans. We have studied the Ras-MAPK pathway in the plant parasitic nematode Meloidogyne artiellia. The genes Mt-let-60, Mt-lin-45, Mt-mek-2 and Mt-mpk-1 have been isolated and sequenced. Each of them shows a high level of sequence similarity to its presumed ortholog in C. elegans and key functional domains are structurally conserved. Furthermore, we show that the M. artiellia recombinant MEK-2 protein can phosphorylate and activate the M. artiellia recombinant MPK-1 and the recombinant MEK-2 itself can be phosphorylated and activated by immunoprecipitated mammalian Raf. Surprisingly, the Mt-lin-45 message is not detectable in freshly emerged juveniles or in male specimens, suggesting that it may be quickly degraded in these life stages.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0166-6851
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
149
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
38-47
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:16737746-Amino Acid Sequence,
pubmed-meshheading:16737746-Animals,
pubmed-meshheading:16737746-Caenorhabditis elegans,
pubmed-meshheading:16737746-Caenorhabditis elegans Proteins,
pubmed-meshheading:16737746-Cicer,
pubmed-meshheading:16737746-Female,
pubmed-meshheading:16737746-Gene Expression Regulation, Developmental,
pubmed-meshheading:16737746-Helminth Proteins,
pubmed-meshheading:16737746-MAP Kinase Kinase 2,
pubmed-meshheading:16737746-Male,
pubmed-meshheading:16737746-Mitogen-Activated Protein Kinases,
pubmed-meshheading:16737746-Molecular Sequence Data,
pubmed-meshheading:16737746-Olfactory Pathways,
pubmed-meshheading:16737746-Phosphorylation,
pubmed-meshheading:16737746-Sequence Alignment,
pubmed-meshheading:16737746-Signal Transduction,
pubmed-meshheading:16737746-Tylenchoidea,
pubmed-meshheading:16737746-raf Kinases,
pubmed-meshheading:16737746-ras Proteins
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pubmed:year |
2006
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pubmed:articleTitle |
The expression of the homologue of the Caenorhabditis elegans lin-45 raf is regulated in the motile stages of the plant parasitic nematode Meloidogyne artiellia.
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pubmed:affiliation |
Dipartimento di Biochimica e Biologia Molecolare, Via Orabona 4, 70126 Bari, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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