Source:http://linkedlifedata.com/resource/pubmed/id/16737218
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
|
| pubmed:dateCreated |
2006-6-1
|
| pubmed:abstractText |
The rupture forces between an aptamer (1)-functionalized AFM tip and a thrombin-modified Au surface are analyzed. The rupture force for a single aptamer/thrombin complex is determined as approximately 4.45 pN. The analysis of the system reveals that the rupture forces correspond to the melting of the G-quadruplex structure of the aptamer bound to the thrombin. This melting of the G-quadruplex leads to the dissociation of the aptamer/thrombin complex.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0003-2700
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
78
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
3638-42
|
| pubmed:meshHeading |
pubmed-meshheading:16737218-Aptamers, Nucleotide,
pubmed-meshheading:16737218-Base Sequence,
pubmed-meshheading:16737218-Gold,
pubmed-meshheading:16737218-Hydrogen Bonding,
pubmed-meshheading:16737218-Microscopy, Atomic Force,
pubmed-meshheading:16737218-Molecular Sequence Data,
pubmed-meshheading:16737218-Nucleic Acid Denaturation,
pubmed-meshheading:16737218-Stress, Mechanical,
pubmed-meshheading:16737218-Thrombin
|
| pubmed:year |
2006
|
| pubmed:articleTitle |
Following aptamer-thrombin binding by force measurements.
|
| pubmed:affiliation |
Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.
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| pubmed:publicationType |
Journal Article
|