Linked Life Data

16736948

Source:http://linkedlifedata.com/resource/pubmed/id/16736948

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2006-6-1
pubmed:abstractText
Transmission of HIV viruses harboring resistance mutations is already a major concern in developed countries, with the potential to impact on therapeutic strategies. Several factors influence the transmission of such viruses, including viral replication fitness and transmission fitness, although behavioral characteristics must also be considered. Rates of transmission of specific mutations are related to therapeutic strategies. Reports of the transmission of multidrug-resistant viruses should alarm the medical community. An additional concern is the use of monotherapy with nevirapine for the prevention of mother-to-child transmission of HIV in developing countries as this practice selects for resistance to nonnucleoside reverse transcription inhibitors and could limit future therapeutic options of both the mothers and infected children. HIV treatment guidelines have evolved, shifting from more aggressive to more conservative approaches. This change of strategy has had a direct impact on the prevalence of drug-resistant virus in the population and the transmission of resistant viral species.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1139-6121
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
17-23
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:articleTitle
HIV transmission and primary drug resistance.
pubmed:affiliation
AIDS Center, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel.
pubmed:publicationType
Journal Article, Review