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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2006-8-22
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pubmed:abstractText |
Aberrant activation of Wnt/beta-catenin signaling and subsequent up-regulation of beta-catenin response transcription (CRT) is a critical event in the development of human colon cancer. Thus, Wnt/beta-catenin signaling is an attractive target for the development of anticancer therapeutics. In this study, we identified hexachlorophene as an inhibitor of Wnt/beta-catenin signaling from cell-based small-molecule screening. Hexachlorophene antagonized CRT that was stimulated by Wnt3a-conditioned medium by promoting the degradation of beta-catenin. This degradation pathway is Siah-1 and adenomatous polyposis colidependent, but glycogen synthase kinase-3beta and F-box beta-transducin repeat-containing protein-independent. In addition, hexachlorophene represses the expression of cyclin D1, which is a known beta-catenin target gene, and inhibits the growth of colon cancer cells. Our findings suggest that hexachlorophene attenuates Wnt/beta-catenin signaling through the Siah-1-mediated beta-catenin degradation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Infective Agents, Local,
http://linkedlifedata.com/resource/pubmed/chemical/Glycogen Synthase Kinase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Hexachlorophene,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Protein p53,
http://linkedlifedata.com/resource/pubmed/chemical/Ubiquitin-Protein Ligases,
http://linkedlifedata.com/resource/pubmed/chemical/WNT3A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Wnt Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Wnt3 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Wnt3A Protein,
http://linkedlifedata.com/resource/pubmed/chemical/beta Catenin,
http://linkedlifedata.com/resource/pubmed/chemical/beta-Transducin Repeat-Containing...,
http://linkedlifedata.com/resource/pubmed/chemical/glycogen synthase kinase 3 beta,
http://linkedlifedata.com/resource/pubmed/chemical/seven in absentia proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0026-895X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
70
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
960-6
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:16735606-Anti-Infective Agents, Local,
pubmed-meshheading:16735606-Cell Proliferation,
pubmed-meshheading:16735606-Cells, Cultured,
pubmed-meshheading:16735606-Colonic Neoplasms,
pubmed-meshheading:16735606-Down-Regulation,
pubmed-meshheading:16735606-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:16735606-Glycogen Synthase Kinase 3,
pubmed-meshheading:16735606-Hexachlorophene,
pubmed-meshheading:16735606-Humans,
pubmed-meshheading:16735606-Nuclear Proteins,
pubmed-meshheading:16735606-Protein Processing, Post-Translational,
pubmed-meshheading:16735606-RNA, Messenger,
pubmed-meshheading:16735606-Signal Transduction,
pubmed-meshheading:16735606-Tumor Suppressor Protein p53,
pubmed-meshheading:16735606-Ubiquitin-Protein Ligases,
pubmed-meshheading:16735606-Wnt Proteins,
pubmed-meshheading:16735606-Wnt3 Protein,
pubmed-meshheading:16735606-Wnt3A Protein,
pubmed-meshheading:16735606-beta Catenin,
pubmed-meshheading:16735606-beta-Transducin Repeat-Containing Proteins
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pubmed:year |
2006
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pubmed:articleTitle |
Hexachlorophene inhibits Wnt/beta-catenin pathway by promoting Siah-mediated beta-catenin degradation.
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pubmed:affiliation |
PharmcoGenomics Research Center, Inje University, Busan 614-735, Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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