| pubmed-article:16734623 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16734623 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:16734623 | lifeskim:mentions | umls-concept:C0026764 | lld:lifeskim |
| pubmed-article:16734623 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:16734623 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:16734623 | lifeskim:mentions | umls-concept:C0596402 | lld:lifeskim |
| pubmed-article:16734623 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
| pubmed-article:16734623 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:16734623 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:16734623 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
| pubmed-article:16734623 | lifeskim:mentions | umls-concept:C2709199 | lld:lifeskim |
| pubmed-article:16734623 | lifeskim:mentions | umls-concept:C1511636 | lld:lifeskim |
| pubmed-article:16734623 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:16734623 | lifeskim:mentions | umls-concept:C0205296 | lld:lifeskim |
| pubmed-article:16734623 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:16734623 | pubmed:dateCreated | 2006-5-31 | lld:pubmed |
| pubmed-article:16734623 | pubmed:abstractText | gammadelta T cells account for up to 10% of T lymphocytes in the peripheral blood of healthy donors. They can be activated by cytokines such as interleukin (IL)-2, IL-12 and IL-15, express natural killer (NK) cell markers such as NKG2D and show cytotoxic activity against several tumour cells, including multiple myeloma. Here, we present activated polyclonal gammadelta T cells from healthy donors with an NK T cell-like phenotype expressing the natural cytotoxicity receptor NKp44. Natural cytotoxicity receptors NKp30, NKp44 and NKp46 have been regarded as specific NK receptors; only two gammadelta T cell clones described so far expressed NKp 44. Isolated polyclonal gammadelta T cells cultured for 7 days according to the cytokine-induced killer cell (CIK) protocol with additional IL-15 revealed a surface expression of NKp44 of 8+/-7% (n=22). This could be confirmed by detection of NKp 44 mRNA by reverse transcription-polymerase chain reaction (RT-PCR). gammadelta T cells exhibited a marked cytotoxic activity against myeloma cells, which could be reduced by inhibition of NKp44. To our knowledge, this is the first description of the expression of NKp44 on polyclonal gammadelta T cells. | lld:pubmed |
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| pubmed-article:16734623 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16734623 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16734623 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16734623 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16734623 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:16734623 | pubmed:issn | 0009-9104 | lld:pubmed |
| pubmed-article:16734623 | pubmed:author | pubmed-author:FeldmannGG | lld:pubmed |
| pubmed-article:16734623 | pubmed:author | pubmed-author:FrankSS | lld:pubmed |
| pubmed-article:16734623 | pubmed:author | pubmed-author:SieversEE | lld:pubmed |
| pubmed-article:16734623 | pubmed:author | pubmed-author:StrehlJJ | lld:pubmed |
| pubmed-article:16734623 | pubmed:author | pubmed-author:NattermannJJ | lld:pubmed |
| pubmed-article:16734623 | pubmed:author | pubmed-author:von... | lld:pubmed |
| pubmed-article:16734623 | pubmed:author | pubmed-author:Schmidt-WolfI... | lld:pubmed |
| pubmed-article:16734623 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16734623 | pubmed:volume | 144 | lld:pubmed |
| pubmed-article:16734623 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16734623 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16734623 | pubmed:pagination | 528-33 | lld:pubmed |
| pubmed-article:16734623 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:16734623 | pubmed:meshHeading | pubmed-meshheading:16734623... | lld:pubmed |
| pubmed-article:16734623 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16734623 | pubmed:articleTitle | Activated gammadelta T cells express the natural cytotoxicity receptor natural killer p 44 and show cytotoxic activity against myeloma cells. | lld:pubmed |
| pubmed-article:16734623 | pubmed:affiliation | Medizinische Klinik und Poliklinik I, Universitätsklinikum Bonn, Sigmund Freud Str. 25, 53105 Bonn, Germany. m.lilienfeld.toal@uni-bonn.de | lld:pubmed |
| pubmed-article:16734623 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16734623 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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