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rdf:type |
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lifeskim:mentions |
umls-concept:C0007634,
umls-concept:C0017262,
umls-concept:C0026764,
umls-concept:C0039194,
umls-concept:C0205296,
umls-concept:C0441655,
umls-concept:C0596402,
umls-concept:C0597357,
umls-concept:C1171362,
umls-concept:C1511636,
umls-concept:C1515670,
umls-concept:C1879547,
umls-concept:C2709199
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pubmed:issue |
3
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pubmed:dateCreated |
2006-5-31
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pubmed:abstractText |
gammadelta T cells account for up to 10% of T lymphocytes in the peripheral blood of healthy donors. They can be activated by cytokines such as interleukin (IL)-2, IL-12 and IL-15, express natural killer (NK) cell markers such as NKG2D and show cytotoxic activity against several tumour cells, including multiple myeloma. Here, we present activated polyclonal gammadelta T cells from healthy donors with an NK T cell-like phenotype expressing the natural cytotoxicity receptor NKp44. Natural cytotoxicity receptors NKp30, NKp44 and NKp46 have been regarded as specific NK receptors; only two gammadelta T cell clones described so far expressed NKp 44. Isolated polyclonal gammadelta T cells cultured for 7 days according to the cytokine-induced killer cell (CIK) protocol with additional IL-15 revealed a surface expression of NKp44 of 8+/-7% (n=22). This could be confirmed by detection of NKp 44 mRNA by reverse transcription-polymerase chain reaction (RT-PCR). gammadelta T cells exhibited a marked cytotoxic activity against myeloma cells, which could be reduced by inhibition of NKp44. To our knowledge, this is the first description of the expression of NKp44 on polyclonal gammadelta T cells.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16734623-10049942,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16734623-10090953,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16734623-10359807,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16734623-10397734,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16734623-10426993,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16734623-10426994,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16734623-10562324,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16734623-10887096,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16734623-11023518,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16734623-11491531,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16734623-11536166,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16734623-11544298,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16734623-11567106,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16734623-11602408,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16734623-11673519,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16734623-12384702,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16734623-12414645,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16734623-12538656,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16734623-12623838,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16734623-12714493,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16734623-14707061,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16734623-15328155,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16734623-15894118,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16734623-1711560,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16734623-3926660,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16734623-4097745,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16734623-6042436,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16734623-8152260,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16734623-8200042,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16734623-8599969,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16734623-9625766,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16734623-9730896,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16734623-9973456
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-15,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/NCR2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Natural Cytotoxicity Triggering...,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0009-9104
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
144
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
528-33
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:16734623-Cells, Cultured,
pubmed-meshheading:16734623-Cytotoxicity, Immunologic,
pubmed-meshheading:16734623-Gene Expression Regulation,
pubmed-meshheading:16734623-Humans,
pubmed-meshheading:16734623-Immunophenotyping,
pubmed-meshheading:16734623-Interleukin-15,
pubmed-meshheading:16734623-Interleukin-2,
pubmed-meshheading:16734623-Killer Cells, Natural,
pubmed-meshheading:16734623-Lymphocyte Activation,
pubmed-meshheading:16734623-Multiple Myeloma,
pubmed-meshheading:16734623-Natural Cytotoxicity Triggering Receptor 2,
pubmed-meshheading:16734623-RNA, Messenger,
pubmed-meshheading:16734623-Receptors, Antigen, T-Cell, gamma-delta,
pubmed-meshheading:16734623-Receptors, Immunologic,
pubmed-meshheading:16734623-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:16734623-Tumor Cells, Cultured
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pubmed:year |
2006
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pubmed:articleTitle |
Activated gammadelta T cells express the natural cytotoxicity receptor natural killer p 44 and show cytotoxic activity against myeloma cells.
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pubmed:affiliation |
Medizinische Klinik und Poliklinik I, Universitätsklinikum Bonn, Sigmund Freud Str. 25, 53105 Bonn, Germany. m.lilienfeld.toal@uni-bonn.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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