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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2006-8-31
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pubmed:abstractText |
Apoptosis is an essential physiological process that regulates cellular proliferation. Here, we explored the effect of DNA sequence variation within the BCL-2 gene on prostate cancer susceptibility in three clinical populations, consisting of 428 African Americans, 214 Jamaicans and 218 European Americans. We observed a 70% reduced risk for prostate cancer among the European Americans who had possessed two copies of a promoter variant -938C/A. Additionally, common BCL-2 haplotypes appeared to influence prostate cancer risk; however, studies in larger data sets are needed to confirm our findings. Our data suggest that inherited BCL-2 variants may be associated with a decrease in prostate cancer susceptibility.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1365-7852
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pubmed:author |
pubmed-author:AhaghotuCC,
pubmed-author:AkereyeniFF,
pubmed-author:BonillaCC,
pubmed-author:ChenWW,
pubmed-author:CoulibalyAA,
pubmed-author:FreemanVV,
pubmed-author:IsaacsWW,
pubmed-author:KiddL RLR,
pubmed-author:KittlesR ARA,
pubmed-author:MasonTT,
pubmed-author:OONOFF,
pubmed-author:TempletonT MTM
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pubmed:issnType |
Print
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
284-92
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:16733517-Adult,
pubmed-meshheading:16733517-African Americans,
pubmed-meshheading:16733517-Aged,
pubmed-meshheading:16733517-Aged, 80 and over,
pubmed-meshheading:16733517-Carcinoma,
pubmed-meshheading:16733517-Case-Control Studies,
pubmed-meshheading:16733517-European Continental Ancestry Group,
pubmed-meshheading:16733517-Gene Frequency,
pubmed-meshheading:16733517-Genetic Predisposition to Disease,
pubmed-meshheading:16733517-Genetic Variation,
pubmed-meshheading:16733517-Genotype,
pubmed-meshheading:16733517-Germ-Line Mutation,
pubmed-meshheading:16733517-Haplotypes,
pubmed-meshheading:16733517-Humans,
pubmed-meshheading:16733517-Inheritance Patterns,
pubmed-meshheading:16733517-Jamaica,
pubmed-meshheading:16733517-Linkage Disequilibrium,
pubmed-meshheading:16733517-Male,
pubmed-meshheading:16733517-Middle Aged,
pubmed-meshheading:16733517-Models, Biological,
pubmed-meshheading:16733517-Open Reading Frames,
pubmed-meshheading:16733517-Prostatic Neoplasms,
pubmed-meshheading:16733517-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:16733517-Regulatory Elements, Transcriptional
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pubmed:year |
2006
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pubmed:articleTitle |
Germline BCL-2 sequence variants and inherited predisposition to prostate cancer.
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pubmed:affiliation |
Cancer Prevention and Control Program, Department of Pharmacology and Toxicology, James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, KY, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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