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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2006-7-25
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pubmed:abstractText |
The effect of deoxypodophyllotoxin (DPT) isolated from Anthriscus sylvestris Hoffm. was evaluated in an IN VIVO animal model for antiasthmatic activity. DPT (1.0 to 5 mg/kg) was given orally to ovalbumin (OVA)/alum-induced asthmatic mice. DPT reduced the number of infiltrated eosinophils in bronchoalveolar lavage (BAL) fluid in a dose-dependent manner. Dexamethasone (5 mg/kg), which was used as a positive control, also strongly inhibited the number of infiltrated eosinophils. The effect of DPT on a transcript profile in a murine asthma model was determined by RT-PCR, which showed that DPT decreased the mRNA levels of the Th2 cytokines. Northern blot analysis showed that DPT also reduced both the eotaxin and arginase I mRNA levels in a dose-dependent manner.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Asthmatic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Arginase,
http://linkedlifedata.com/resource/pubmed/chemical/Ccl11 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL11,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokines, CC,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Ovalbumin,
http://linkedlifedata.com/resource/pubmed/chemical/Plant Preparations,
http://linkedlifedata.com/resource/pubmed/chemical/Podophyllotoxin,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Isoforms,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/deoxypodophyllotoxin
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0032-0943
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pubmed:author |
pubmed-author:ChangHyeun WookHW,
pubmed-author:HaKyungmiK,
pubmed-author:JinMei HuaMH,
pubmed-author:KimKeuk JunKJ,
pubmed-author:KimMi JinMJ,
pubmed-author:LeeEunkyungE,
pubmed-author:LeeSeung HoSH,
pubmed-author:LinChang XinCX,
pubmed-author:MoonTae ChulTC,
pubmed-author:QuanZhejiuZ,
pubmed-author:YookJuminJ
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pubmed:issnType |
Print
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pubmed:volume |
72
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
786-91
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:16732515-Animals,
pubmed-meshheading:16732515-Anti-Asthmatic Agents,
pubmed-meshheading:16732515-Apiaceae,
pubmed-meshheading:16732515-Arginase,
pubmed-meshheading:16732515-Asthma,
pubmed-meshheading:16732515-Cell Movement,
pubmed-meshheading:16732515-Chemokine CCL11,
pubmed-meshheading:16732515-Chemokines, CC,
pubmed-meshheading:16732515-Cytokines,
pubmed-meshheading:16732515-Eosinophils,
pubmed-meshheading:16732515-Female,
pubmed-meshheading:16732515-Gene Expression Regulation,
pubmed-meshheading:16732515-Mice,
pubmed-meshheading:16732515-Mice, Inbred BALB C,
pubmed-meshheading:16732515-Ovalbumin,
pubmed-meshheading:16732515-Plant Preparations,
pubmed-meshheading:16732515-Pneumonia,
pubmed-meshheading:16732515-Podophyllotoxin,
pubmed-meshheading:16732515-Protein Isoforms,
pubmed-meshheading:16732515-RNA, Messenger,
pubmed-meshheading:16732515-Th2 Cells
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pubmed:year |
2006
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pubmed:articleTitle |
Deoxypodophyllotoxin (DPT) inhibits eosinophil recruitment into the airway and Th2 cytokine expression in an OVA-induced lung inflammation.
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pubmed:affiliation |
College of Pharmacy, Yeungnam University, Gyongsan, Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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