|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
7
|
|
pubmed:dateCreated |
2006-6-27
|
|
pubmed:abstractText |
The core and shell of the nucleus accumbens have critical, differential roles in drug-dependent behaviors. Here we show that operant cocaine self-administration inhibits long-term depression (LTD) in both structures after 1 d of abstinence. However, after 21 d of abstinence, LTD was abolished exclusively in the nucleus accumbens core of cocaine self-administering rats, suggesting that voluntary cocaine self-administration induced long-lasting neuroadaptations in the core that could underlie drug-seeking behavior and relapse.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
1097-6256
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
9
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
868-9
|
|
pubmed:dateRevised |
2007-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:16732275-Animals,
pubmed-meshheading:16732275-Behavior, Addictive,
pubmed-meshheading:16732275-Behavior, Animal,
pubmed-meshheading:16732275-Cocaine,
pubmed-meshheading:16732275-Conditioning, Operant,
pubmed-meshheading:16732275-Dopamine Uptake Inhibitors,
pubmed-meshheading:16732275-Electric Stimulation,
pubmed-meshheading:16732275-Long-Term Synaptic Depression,
pubmed-meshheading:16732275-Male,
pubmed-meshheading:16732275-Neurons,
pubmed-meshheading:16732275-Nucleus Accumbens,
pubmed-meshheading:16732275-Rats,
pubmed-meshheading:16732275-Rats, Sprague-Dawley,
pubmed-meshheading:16732275-Reinforcement (Psychology),
pubmed-meshheading:16732275-Reinforcement Schedule,
pubmed-meshheading:16732275-Self Administration,
pubmed-meshheading:16732275-Time Factors
|
|
pubmed:year |
2006
|
|
pubmed:articleTitle |
Cocaine self-administration selectively abolishes LTD in the core of the nucleus accumbens.
|
|
pubmed:affiliation |
Ernest Gallo Clinic and Research Center, 5858 Horton Street, Suite 200, Emeryville, California 94608, USA.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
In Vitro,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|
