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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2006-5-29
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pubmed:abstractText |
Only five monoclonal antibodies (MAbs) neutralizing a broad range of primary isolates (PI) have been identified up to now. We have found that some MAbs with no neutralizing activities according to the "conventional" neutralization assay, involving phytohemagglutinin-stimulated peripheral blood mononuclear cells as targets, efficiently inhibit the replication of human immunodeficiency virus type 1 (HIV-1) PI in macrophages and immature dendritic cells (iDC). The mechanism of inhibition is distinct from the neutralization of infectivity occurring via Fab fragments and involves the interaction of the F portion with the FcgammaRs present on macrophages and iDC. We propose that, if such nonneutralizing inhibitory antibodies limit mucosal HIV transmission, they should be induced by vaccination.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16731957-10655111,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16731957-11044111,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16731957-12088685,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16731957-12103427,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16731957-12689409,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16731957-14627745,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16731957-15528366,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16731957-15603449,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16731957-15609004,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16731957-15708596,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16731957-16227256,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16731957-1714520,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16731957-8035514,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16731957-9094648,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16731957-9310831,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16731957-9764911
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
80
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6177-81
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:16731957-Cell Line,
pubmed-meshheading:16731957-Dendritic Cells,
pubmed-meshheading:16731957-HIV Antibodies,
pubmed-meshheading:16731957-HIV-1,
pubmed-meshheading:16731957-Humans,
pubmed-meshheading:16731957-Immunoglobulin Fab Fragments,
pubmed-meshheading:16731957-Macrophages,
pubmed-meshheading:16731957-Neutralization Tests,
pubmed-meshheading:16731957-Receptors, IgG,
pubmed-meshheading:16731957-Virus Replication
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pubmed:year |
2006
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pubmed:articleTitle |
Nonneutralizing antibodies are able to inhibit human immunodeficiency virus type 1 replication in macrophages and immature dendritic cells.
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pubmed:affiliation |
EA 3770, ULP, Institut de Virologie, 3 rue Koeberlé, F-67000 Strasbourg, France.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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