Source:http://linkedlifedata.com/resource/pubmed/id/16731854
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
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| pubmed:dateCreated |
2006-5-29
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| pubmed:abstractText |
To elucidate the genetic factors contributing to heterogeneity of the rate of beta-cell destruction in type 1 diabetes, we investigated the relationship between the time course of complete beta-cell loss and HLA class I and II alleles. HLA allele frequencies were also examined among subgroups classified by the mode of onset. The subjects were 266 type 1 diabetic patients (among whom 196 patients were studied longitudinally) and 136 normal control subjects. Earlier complete loss of beta-cell function was observed in patients who possessed both HLA-A24 and HLA-DQA1*03 and in patients who had HLA-DR9, compared with those without these HLA alleles (P=0.0057 and 0.0093, respectively). Much earlier complete beta-cell loss was observed in the patients who possessed all of HLA-A24, -DQA1*03, and -DR9 compared with the remaining patients (P=0.0011). The combination of HLA-A24, -DQA1*03, and -DR9 showed a higher frequency in acute-onset than slow-onset type 1 diabetes (P=0.0002). In contrast, HLA-DR2 was associated with a slower rate of progression to complete beta-cell loss. These results indicate that the combination of HLA-A24, -DQA1*03, and -DR9 contributes to the acute-onset and early complete beta-cell destruction, whereas HLA-DR2 has a protective effect against complete beta-cell loss in type 1 diabetes.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/C-Peptide,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-A Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-A24 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DQ Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DQ alpha-Chains,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DQA1 antigen,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DR Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DR Serological Subtypes,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DR9 antigen
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jun
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| pubmed:issn |
0012-1797
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
55
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1862-8
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:16731854-Adult,
pubmed-meshheading:16731854-Age of Onset,
pubmed-meshheading:16731854-Alleles,
pubmed-meshheading:16731854-C-Peptide,
pubmed-meshheading:16731854-Diabetes Mellitus, Type 1,
pubmed-meshheading:16731854-Female,
pubmed-meshheading:16731854-Gene Frequency,
pubmed-meshheading:16731854-HLA-A Antigens,
pubmed-meshheading:16731854-HLA-A24 Antigen,
pubmed-meshheading:16731854-HLA-DQ Antigens,
pubmed-meshheading:16731854-HLA-DQ alpha-Chains,
pubmed-meshheading:16731854-HLA-DR Antigens,
pubmed-meshheading:16731854-HLA-DR Serological Subtypes,
pubmed-meshheading:16731854-Humans,
pubmed-meshheading:16731854-Incidence,
pubmed-meshheading:16731854-Insulin-Secreting Cells,
pubmed-meshheading:16731854-Japan,
pubmed-meshheading:16731854-Longitudinal Studies,
pubmed-meshheading:16731854-Male,
pubmed-meshheading:16731854-Middle Aged,
pubmed-meshheading:16731854-Multivariate Analysis,
pubmed-meshheading:16731854-Polymorphism, Restriction Fragment Length
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| pubmed:year |
2006
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| pubmed:articleTitle |
Combination of HLA-A24, -DQA1*03, and -DR9 contributes to acute-onset and early complete beta-cell destruction in type 1 diabetes: longitudinal study of residual beta-cell function.
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| pubmed:affiliation |
Department of Endocrinology and Metabolism, Toranomon Hospital, 2-2-2 Toranomon, Minato-ku, Tokyo 105-8470, Japan. koji01@toranomon.gr.jp
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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