Linked Life Data

16731835

Source:http://linkedlifedata.com/resource/pubmed/id/16731835

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2006-5-29
pubmed:abstractText
Adiponectin (APM1) is an adipocyte-derived peptide that contributes to glucose, lipid, and energy homeostasis. We assessed the genetic basis of plasma adiponectin in Hispanic-American and African-American families enrolled through the Insulin Resistance Atherosclerosis Study Family Study. A 10-cM genome scan was performed in two batches: an original set (set 1) consisting of 66 families (45 Hispanic American and 21 African American) and a replication set (set 2) consisting of 66 families (45 Hispanic American and 21 African American). Adiponectin levels were measured by radioimmunoassay in 1,727 individuals from 131 of 132 families. Linkage analysis was carried out in Hispanic Americans and African Americans separately in set 1, set 2, and the pooled set (set 1 plus set 2), with and without diabetic subjects. A major gene was mapped to 3q27 with a logarithm of odds (LOD) score of 8.21 in the Hispanic-American sample. Ninety-six unrelated individuals were screened for polymorphisms in the APM1 gene, and 18 single nucleotide polymorphisms (SNPs) were genotyped in the Hispanic-American sample. Plasma adiponectin level was modestly associated with two SNPs and their accompaning haplotypes. Incorporating each or both SNPs in the linkage analysis, however, did not significantly reduce the LOD score. Therefore, a quantitative trait locus at 3q27, likely distinct from the APM1 gene, contributes to the variation of plasma adiponectin levels in the Hispanic-American population.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0012-1797
pubmed:author
pubmed:issnType
Print
pubmed:volume
55
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1723-30
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:16731835-Adiponectin, pubmed-meshheading:16731835-Adult, pubmed-meshheading:16731835-African Americans, pubmed-meshheading:16731835-Chromosome Mapping, pubmed-meshheading:16731835-Chromosomes, Human, Pair 3, pubmed-meshheading:16731835-Diabetes Mellitus, pubmed-meshheading:16731835-Female, pubmed-meshheading:16731835-Genetic Linkage, pubmed-meshheading:16731835-Genetic Predisposition to Disease, pubmed-meshheading:16731835-Genome, Human, pubmed-meshheading:16731835-Genotype, pubmed-meshheading:16731835-Haplotypes, pubmed-meshheading:16731835-Hispanic Americans, pubmed-meshheading:16731835-Humans, pubmed-meshheading:16731835-Lod Score, pubmed-meshheading:16731835-Male, pubmed-meshheading:16731835-Middle Aged, pubmed-meshheading:16731835-Polymorphism, Single Nucleotide, pubmed-meshheading:16731835-Quantitative Trait Loci
pubmed:year
2006
pubmed:articleTitle
Genome-wide linkage of plasma adiponectin reveals a major locus on chromosome 3q distinct from the adiponectin structural gene: the IRAS family study.
pubmed:affiliation
Medical Genetics Institutes, Cedars-Sinai Medical Center, 8700 Beverly Blvd., 665W, Los Angeles, CA 90048, USA. xiuqing.guo@cshs.org
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural