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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1991-5-20
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pubmed:abstractText |
Within 6 months of infection with the Petaluma isolate of feline immunodeficiency virus, specific-pathogen-free domestic cats exhibited a decrease in the percentage and number of circulating CD4+ lymphocytes and in the CD4+/CD8+ T-cell ratio, along with a marginally significant depression of pokeweed mitogen-induced lymphocyte proliferation in vitro. There was no loss of responsiveness to concanavalin A during this stage, and the cats were capable of mounting a satisfactory antibody response to a T-dependent, synthetic polypeptide immunogen. The pokeweed mitogen response deficit became clearly demonstrable by 11 to 12 months postinfection. A decline in the lymphocyte proliferative response to concanavalin A and a diminished ability to mount an in vivo antibody response to the T-dependent immunogen evolved by 25 to 44 months postinfection. Virus infection did not affect the ability of cats to mount an antibody response to a T-independent synthetic polypeptide immunogen. These data indicate that feline immunodeficiency virus produces a slowly progressive deterioration of T-cell function but does not affect the ability of B cells to recognize and respond to a T-independent antigenic stimulus.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1673159-1671410,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1673159-1967191,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1673159-1969282,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1673159-1972217,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1673159-2103733,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1673159-2153226,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1673159-2166850,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1673159-2166852,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1673159-2166854,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1673159-2188396,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1673159-2459996,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1673159-2537269,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1673159-2537270,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1673159-2537271,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1673159-2541167,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1673159-2549690,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1673159-2554557,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1673159-2556312,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1673159-2557380,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1673159-2558688,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1673159-2654428,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1673159-2683820,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1673159-2738584,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1673159-2950813,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1673159-2974045,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1673159-2975974,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1673159-3016902,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1673159-3076366,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1673159-3081644,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1673159-3105779,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1673159-3183430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1673159-3493285,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1673159-3494857,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1673159-3643650,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1673159-4115955,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1673159-5699055,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1673159-5807278,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1673159-6224088,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1673159-6254637,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1673159-6287820
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD4,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD8,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Concanavalin A,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Pokeweed Mitogens
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
65
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2225-30
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1673159-Amino Acid Sequence,
pubmed-meshheading:1673159-Animals,
pubmed-meshheading:1673159-Antibodies, Viral,
pubmed-meshheading:1673159-Antigens, CD4,
pubmed-meshheading:1673159-Antigens, CD8,
pubmed-meshheading:1673159-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:1673159-CD4-Positive T-Lymphocytes,
pubmed-meshheading:1673159-Cats,
pubmed-meshheading:1673159-Concanavalin A,
pubmed-meshheading:1673159-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:1673159-Feline Acquired Immunodeficiency Syndrome,
pubmed-meshheading:1673159-Immunodeficiency Virus, Feline,
pubmed-meshheading:1673159-Molecular Sequence Data,
pubmed-meshheading:1673159-Peptides,
pubmed-meshheading:1673159-Pokeweed Mitogens,
pubmed-meshheading:1673159-Specific Pathogen-Free Organisms,
pubmed-meshheading:1673159-T-Lymphocytes, Regulatory
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pubmed:year |
1991
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pubmed:articleTitle |
Progressive immune dysfunction in cats experimentally infected with feline immunodeficiency virus.
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pubmed:affiliation |
Department of Medicine, School of Veterinary Medicine, University of California, Davis 95616.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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