Linked Life Data

1673140

Source:http://linkedlifedata.com/resource/pubmed/id/1673140

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1991-5-21
pubmed:abstractText
MLR in various combinations with class I H-2 disparity revealed that there are three patterns of MLR in the aspect of responding T subset (CD4 vs CD8) dominance. Irrespective of the CD8 vs CD4 dominance, a single i.v. administration of class I-disparate allogeneic spleen cells resulted in almost complete abrogation of anti-class I proliferative capacity of both CD4+ and CD8+ T cells in six combinations. The suppression of proliferative responses was correlated with the striking reduction in the ability to produce IL-2 upon stimulation with the relevant class I alloantigens. In contrast, i.v. presensitized recipient mice exhibiting only marginal MLR/Il-2 production could generate comparable magnitudes of anti-allo class I CTL as well as graft rejection responses to those induced by normal unpresensitized mice. The administration in vivo of anti-CD4 antibody along with the i.v. presensitization not only suppressed the generation of CTL responses by spleen cells but also induced appreciable prolongation of allo-class I-disparate skin grafts under conditions in which neither alone did it. These results demonstrate that 1) the suppression of graft rejection responses is not necessarily reflected on the reduction of MLR; 2) CD8+ CTL precursors responsible for graft rejection can be activated by either allo-class I-reactive CD8+ or CD4+ Th cells; 3) i.v. presensitization induces functional elimination of CD8+ and CD4+ proliferative/IL-2-producing T cells but not of CD8+ CTL precursors and CD4+ Th whose capacity is expressed by assistance of CTL induction but not by their own proliferation. Thus, this study illustrates the heterogeneity of class I alloantigen-reactive CD4+ T cells in the aspect of their capacity to proliferate themselves vs contribute to CTL induction as well as graft rejection.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0022-1767
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
146
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2513-21
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:1673140-Animals, pubmed-meshheading:1673140-Antigens, CD4, pubmed-meshheading:1673140-Antigens, CD8, pubmed-meshheading:1673140-Antigens, Differentiation, T-Lymphocyte, pubmed-meshheading:1673140-CD4-Positive T-Lymphocytes, pubmed-meshheading:1673140-Cell Division, pubmed-meshheading:1673140-Cells, Cultured, pubmed-meshheading:1673140-Graft Rejection, pubmed-meshheading:1673140-H-2 Antigens, pubmed-meshheading:1673140-Immune Tolerance, pubmed-meshheading:1673140-Interleukin-2, pubmed-meshheading:1673140-Isoantigens, pubmed-meshheading:1673140-Lymphocyte Culture Test, Mixed, pubmed-meshheading:1673140-Mice, pubmed-meshheading:1673140-Mice, Inbred Strains, pubmed-meshheading:1673140-Spleen, pubmed-meshheading:1673140-T-Lymphocytes, Cytotoxic, pubmed-meshheading:1673140-T-Lymphocytes, Helper-Inducer, pubmed-meshheading:1673140-Thymus Gland
pubmed:year
1991
pubmed:articleTitle
Heterogeneity of CD4+ T cells involved in anti-allo-class I H-2 immune responses. Functional discrimination between the major proliferating cells and helper cells assisting cytotoxic T cell responses.
pubmed:affiliation
Biomedical Research Center, Osaka University Medical School, Japan.
pubmed:publicationType
Journal Article, Comparative Study, In Vitro, Research Support, Non-U.S. Gov't