| pubmed-article:16730097 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16730097 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:16730097 | lifeskim:mentions | umls-concept:C0382336 | lld:lifeskim |
| pubmed-article:16730097 | lifeskim:mentions | umls-concept:C0009647 | lld:lifeskim |
| pubmed-article:16730097 | lifeskim:mentions | umls-concept:C0039593 | lld:lifeskim |
| pubmed-article:16730097 | lifeskim:mentions | umls-concept:C0022885 | lld:lifeskim |
| pubmed-article:16730097 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:16730097 | lifeskim:mentions | umls-concept:C0205250 | lld:lifeskim |
| pubmed-article:16730097 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:16730097 | pubmed:dateCreated | 2006-8-15 | lld:pubmed |
| pubmed-article:16730097 | pubmed:abstractText | Different reports suggest that nociceptin/orphanin FQ (N/OFQ) may have either anxiolytic- or anxiogenic-like effect in rodents. Since N/OFQ elicits hypolocomotion, which undergoes rapid tolerance, and hypolocomotion may be associated to emotional consequences, the present study was designed to investigate the effect of N/OFQ on anxiety after development of tolerance to its hypolocomotor effect. The effect of single or double intracerebroventricular (i.c.v.) injection of N/OFQ was evaluated on anxiety-related behaviors in rats, in the elevated plus maze (EPM) and conditioned defensive burying (CDB) tests. After single administration, N/OFQ displayed an anxiogenic-like pattern of response on the elevated plus maze but hypolocomotion was also observed. Conversely, in the CDB test, N/OFQ induced a clear-cut anxiolytic pattern. To produce tolerance to N/OFQ-induced hypolocomotion the peptide was administered by two i.c.v. injections separated by 120 min; in these conditions it decreased the expression of anxiety-related behaviors in both tests without affecting locomotor activity. The nociceptin/orphanin FQ peptide (NOP) receptor antagonist UFP-101 significantly reduced the effects of N/OFQ to control values in either tests. Corticosterone levels were significantly increased after a single N/OFQ administration (not in a dose-dependent manner) but this increase did not reach significance after double administration (1 nmol/rat). Our results support the idea that N/OFQ may act as an anxiolytic-like agent in the rat; the apparent anxiogenic-like effect observed following its single administration in the EPM may be consequent to its effect on locomotion. | lld:pubmed |
| pubmed-article:16730097 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16730097 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16730097 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16730097 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16730097 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16730097 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16730097 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16730097 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16730097 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:16730097 | pubmed:issn | 0196-9781 | lld:pubmed |
| pubmed-article:16730097 | pubmed:author | pubmed-author:MassiMaurizio... | lld:pubmed |
| pubmed-article:16730097 | pubmed:author | pubmed-author:GiovanniVital... | lld:pubmed |
| pubmed-article:16730097 | pubmed:author | pubmed-author:ArlettiRossan... | lld:pubmed |
| pubmed-article:16730097 | pubmed:author | pubmed-author:CifaniCarloC | lld:pubmed |
| pubmed-article:16730097 | pubmed:author | pubmed-author:RuggieriValen... | lld:pubmed |
| pubmed-article:16730097 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16730097 | pubmed:volume | 27 | lld:pubmed |
| pubmed-article:16730097 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16730097 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16730097 | pubmed:pagination | 2193-200 | lld:pubmed |
| pubmed-article:16730097 | pubmed:meshHeading | pubmed-meshheading:16730097... | lld:pubmed |
| pubmed-article:16730097 | pubmed:meshHeading | pubmed-meshheading:16730097... | lld:pubmed |
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| pubmed-article:16730097 | pubmed:meshHeading | pubmed-meshheading:16730097... | lld:pubmed |
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| pubmed-article:16730097 | pubmed:meshHeading | pubmed-meshheading:16730097... | lld:pubmed |
| pubmed-article:16730097 | pubmed:meshHeading | pubmed-meshheading:16730097... | lld:pubmed |
| pubmed-article:16730097 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16730097 | pubmed:articleTitle | Anxiolytic-like effects of nociceptin/orphanin FQ in the elevated plus maze and in the conditioned defensive burying test in rats. | lld:pubmed |
| pubmed-article:16730097 | pubmed:affiliation | Department of Biomedical Sciences, Section of Pharmacology, University of Modena and Reggio Emilia, I-41100 Modena, Italy. vitale.giovanni@unimore.it | lld:pubmed |
| pubmed-article:16730097 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16730097 | lld:pubmed |
