Source:http://linkedlifedata.com/resource/pubmed/id/16730097
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
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| pubmed:dateCreated |
2006-8-15
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| pubmed:abstractText |
Different reports suggest that nociceptin/orphanin FQ (N/OFQ) may have either anxiolytic- or anxiogenic-like effect in rodents. Since N/OFQ elicits hypolocomotion, which undergoes rapid tolerance, and hypolocomotion may be associated to emotional consequences, the present study was designed to investigate the effect of N/OFQ on anxiety after development of tolerance to its hypolocomotor effect. The effect of single or double intracerebroventricular (i.c.v.) injection of N/OFQ was evaluated on anxiety-related behaviors in rats, in the elevated plus maze (EPM) and conditioned defensive burying (CDB) tests. After single administration, N/OFQ displayed an anxiogenic-like pattern of response on the elevated plus maze but hypolocomotion was also observed. Conversely, in the CDB test, N/OFQ induced a clear-cut anxiolytic pattern. To produce tolerance to N/OFQ-induced hypolocomotion the peptide was administered by two i.c.v. injections separated by 120 min; in these conditions it decreased the expression of anxiety-related behaviors in both tests without affecting locomotor activity. The nociceptin/orphanin FQ peptide (NOP) receptor antagonist UFP-101 significantly reduced the effects of N/OFQ to control values in either tests. Corticosterone levels were significantly increased after a single N/OFQ administration (not in a dose-dependent manner) but this increase did not reach significance after double administration (1 nmol/rat). Our results support the idea that N/OFQ may act as an anxiolytic-like agent in the rat; the apparent anxiogenic-like effect observed following its single administration in the EPM may be consequent to its effect on locomotion.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Sep
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| pubmed:issn |
0196-9781
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
27
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
2193-200
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| pubmed:meshHeading |
pubmed-meshheading:16730097-Animals,
pubmed-meshheading:16730097-Anti-Anxiety Agents,
pubmed-meshheading:16730097-Anxiety,
pubmed-meshheading:16730097-Behavior, Animal,
pubmed-meshheading:16730097-Conditioning (Psychology),
pubmed-meshheading:16730097-Corticosterone,
pubmed-meshheading:16730097-Male,
pubmed-meshheading:16730097-Maze Learning,
pubmed-meshheading:16730097-Neuropsychological Tests,
pubmed-meshheading:16730097-Opioid Peptides,
pubmed-meshheading:16730097-Rats,
pubmed-meshheading:16730097-Rats, Wistar,
pubmed-meshheading:16730097-Signal Transduction
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| pubmed:year |
2006
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| pubmed:articleTitle |
Anxiolytic-like effects of nociceptin/orphanin FQ in the elevated plus maze and in the conditioned defensive burying test in rats.
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| pubmed:affiliation |
Department of Biomedical Sciences, Section of Pharmacology, University of Modena and Reggio Emilia, I-41100 Modena, Italy. vitale.giovanni@unimore.it
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| pubmed:publicationType |
Journal Article
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