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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2006-6-22
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pubmed:abstractText |
Chloroquine is a 9-aminoquinolone with well-known anti-malarial effects. It has biochemical properties that could be applied to inhibit viral replication. We report here that chloroquine is able to inhibit influenza A virus replication, in vitro, and the IC50s of chloroquine against influenza A viruses H1N1 and H3N2 are lower than the plasma concentrations reached during treatment of acute malaria. The potential of chloroquine to be added to the limited range of anti-influenza drugs should be explored further, particularly since antiviral drugs play a vital role in influenza pandemic preparedness.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16729896-11166662,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16729896-12202562,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16729896-12480361,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16729896-14652203,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16729896-15351731,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16729896-16115318,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16729896-16371632,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16729896-16456087,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16729896-16479508,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16729896-7109028,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16729896-8896943
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1743-422X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
39
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
2006
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pubmed:articleTitle |
In vitro inhibition of human influenza A virus replication by chloroquine.
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pubmed:affiliation |
Defence Medical and Environmental Research Institute, DSO National Laboratories, 27 Medical Drive, #09-01, 117510, Singapore. oengeong@dso.org.sg
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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