Source:http://linkedlifedata.com/resource/pubmed/id/16728585
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2006-5-26
|
| pubmed:abstractText |
Blood concentrations of insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3) have recently been associated with breast cancer risk, notably in women who developed breast cancer at a young age. Prospective studies published so far, however, were relatively small and odds ratio (OR) estimates imprecise. We present the results of a large prospective case-control study nested within the European Prospective Investigation into Cancer and Nutrition on total IGF-I, IGFBP-3 and breast cancer risk including 1081 incident cases of invasive breast cancer and 2098 matched control subjects. Increasing IGF-I and IGFBP-3 concentrations were associated with a significant increase in breast cancer risk in women who developed breast cancer after 50 years of age (highest vs lowest quintile OR 1.38 (95% confidence interval (CI) 1.02-1.86), P = 0.01, and 1.44 (95% CI 1.04-1.98), P = 0.01, respectively), but no relationship was observed in younger women (OR = 1.03 (95% CI 0.60-1.77), P = 0.81 for IGF-I, and OR = 0.92 (95% CI 0.50-1.70), P = 0.69 for IGFBP-3). There was, however, significant heterogeneity in the relationship of breast cancer with serum IGF-I and IGFBP-3 levels depending on the time interval between blood donation and tumor diagnosis. A reduction in breast cancer risk with increasing IGF-I concentrations was observed in cases with a diagnosis of cancer less than 2 years after blood donation, (OR = 0.76 (95% CI 0.57-1.03)), while an increase in risk was observed for women with a later diagnosis (above or equal to two years after blood collection, OR = 1.51 (95% CI 1.19-1.91)). A similar pattern was observed for IGFBP-3. This study confirms previous findings for an association of serum IGF-I and IGFBP-3 concentrations with breast cancer risk, particularly for women with a later diagnosis of cancer, but it does not support the hypothesis of an involvement of IGF-I in younger women.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
1351-0088
|
| pubmed:author |
pubmed-author:AgudoAA,
pubmed-author:AllenN ENE,
pubmed-author:BarricarteAA,
pubmed-author:BerrinoFF,
pubmed-author:BiessyCC,
pubmed-author:BinghamSS,
pubmed-author:BoeingHH,
pubmed-author:Boutron-RuaultM CMC,
pubmed-author:Bueno-de-MesquitaH BHB,
pubmed-author:ChirlaqueM DMD,
pubmed-author:Clavel-ChapelonFF,
pubmed-author:DossusLL,
pubmed-author:GonzalezC ACA,
pubmed-author:GrobbeeD EDE,
pubmed-author:KaaksRR,
pubmed-author:KehEE,
pubmed-author:KhawK TKT,
pubmed-author:KolivaMM,
pubmed-author:LahmannP HPH,
pubmed-author:LarrañagaNN,
pubmed-author:LinseisenJJ,
pubmed-author:LukanovaAA,
pubmed-author:NagelGG,
pubmed-author:OlsenAA,
pubmed-author:OvervadKK,
pubmed-author:PallaLL,
pubmed-author:PanicoSS,
pubmed-author:PeetersP H MPH,
pubmed-author:QuirosJ RJR,
pubmed-author:RiboliEE,
pubmed-author:RinaldiSS,
pubmed-author:SacerdoteCC,
pubmed-author:SaracciRR,
pubmed-author:SlimaniNN,
pubmed-author:TéhardBB,
pubmed-author:TjonnelandAA,
pubmed-author:TrichopoulosDD,
pubmed-author:TrichopoulouAA,
pubmed-author:TuminoRR,
pubmed-author:van GilsC HCH,
pubmed-author:van NoordPP
|
| pubmed:issnType |
Print
|
| pubmed:volume |
13
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
593-605
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:16728585-Adult,
pubmed-meshheading:16728585-Breast Neoplasms,
pubmed-meshheading:16728585-Case-Control Studies,
pubmed-meshheading:16728585-Europe,
pubmed-meshheading:16728585-Female,
pubmed-meshheading:16728585-Humans,
pubmed-meshheading:16728585-Incidence,
pubmed-meshheading:16728585-Insulin-Like Growth Factor Binding Protein 3,
pubmed-meshheading:16728585-Insulin-Like Growth Factor I,
pubmed-meshheading:16728585-Middle Aged,
pubmed-meshheading:16728585-Nutritional Physiological Phenomena,
pubmed-meshheading:16728585-Risk Factors
|
| pubmed:year |
2006
|
| pubmed:articleTitle |
IGF-I, IGFBP-3 and breast cancer risk in women: The European Prospective Investigation into Cancer and Nutrition (EPIC).
|
| pubmed:affiliation |
International Agency for Research on Cancer (IARC-WHO), 150 Cours Albert Thomas, 69372 Lyon, Cédex 08, France.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|