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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2006-5-26
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pubmed:abstractText |
Several studies including ours have suggested that lack of CD56 in multiple myeloma (MM) defines a unique patient subset with poorer prognosis. However, the mechanism underlying this aggressive behavior of CD56(-) MM has not been well elucidated. Interleukin-6 (IL-6) or insulin-like growth factor I (IGF-I) induce proliferation of MM cells. In this study, we report about the relationship between CD56 expression and responsiveness to these cytokines.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2-(4-morpholinyl)-8-phenyl-4H-1-benz...,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD56,
http://linkedlifedata.com/resource/pubmed/chemical/Chromones,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin D1,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin-Like Growth Factor I,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/Ki-67 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Morpholines,
http://linkedlifedata.com/resource/pubmed/chemical/Oncogene Protein v-akt,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylinositol 3-Kinases
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0301-472X
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pubmed:author |
pubmed-author:HayashiHideharuH,
pubmed-author:KobayashiMikiM,
pubmed-author:NaitoKensukeK,
pubmed-author:NakamuraSatokiS,
pubmed-author:OhnishiKazunoriK,
pubmed-author:OnoTakaakiT,
pubmed-author:OtsukiTakemiT,
pubmed-author:SaharaNaohiN,
pubmed-author:ShibataKiyoshiK,
pubmed-author:ShigenoKazuyukiK,
pubmed-author:ShinjoKaoriK,
pubmed-author:SugimotoYuyaY,
pubmed-author:TakeshitaAkihiroA
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pubmed:issnType |
Print
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pubmed:volume |
34
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
736-44
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:16728278-Antibodies, Monoclonal,
pubmed-meshheading:16728278-Antigens, CD56,
pubmed-meshheading:16728278-Cell Cycle,
pubmed-meshheading:16728278-Cell Line, Tumor,
pubmed-meshheading:16728278-Cell Proliferation,
pubmed-meshheading:16728278-Chromones,
pubmed-meshheading:16728278-Cyclin D1,
pubmed-meshheading:16728278-Enzyme Inhibitors,
pubmed-meshheading:16728278-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:16728278-Humans,
pubmed-meshheading:16728278-Insulin-Like Growth Factor I,
pubmed-meshheading:16728278-Interleukin-6,
pubmed-meshheading:16728278-Ki-67 Antigen,
pubmed-meshheading:16728278-Morpholines,
pubmed-meshheading:16728278-Multiple Myeloma,
pubmed-meshheading:16728278-Oncogene Protein v-akt,
pubmed-meshheading:16728278-Phosphatidylinositol 3-Kinases,
pubmed-meshheading:16728278-Phosphorylation,
pubmed-meshheading:16728278-Protein Processing, Post-Translational,
pubmed-meshheading:16728278-Signal Transduction
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pubmed:year |
2006
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pubmed:articleTitle |
Role for interleukin-6 and insulin-like growth factor-I via PI3-K/Akt pathway in the proliferation of CD56- and CD56+ multiple myeloma cells.
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pubmed:affiliation |
Internal Medicine III, Hamamatsu University School of Medicine, Hamamatsu, Japan. sahara@hama-med.ac.jp
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pubmed:publicationType |
Journal Article,
Comparative Study
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