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rdf:type |
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lifeskim:mentions |
umls-concept:C0012634,
umls-concept:C0015309,
umls-concept:C0017262,
umls-concept:C0038411,
umls-concept:C0039082,
umls-concept:C0185117,
umls-concept:C0205281,
umls-concept:C0314768,
umls-concept:C0678227,
umls-concept:C1522642,
umls-concept:C1704387,
umls-concept:C1709785,
umls-concept:C1880371,
umls-concept:C2911684
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pubmed:issue |
7
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pubmed:dateCreated |
1991-5-6
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pubmed:abstractText |
Genetic diversity and relationships among 108 isolates of the bacterium Streptococcus pyogenes recently recovered from patients in the United States with toxic-shock-like syndrome or other invasive diseases were estimated by multilocus enzyme electrophoresis. Thirty-three electrophoretic types (ETs), representing distinctive multilocus clonal genotypes, were identified, but nearly half the disease episodes, including more than two-thirds of the cases of toxic-shock-like syndrome, were caused by strains of two related clones (ET 1 and ET 2). These two clones were also represented by recent pathogenic European isolates. A previous report of a relatively high frequency of expression of exotoxin A among isolates recovered from toxic-shock-like syndrome patients in the United States was confirmed; and the demonstration of this association both within clones and among distantly related clones supports the hypothesis that exotoxin A is a causal factor in pathogenesis of this disease. Near identity of the nucleotide sequences of the exotoxin A structural gene of six isolates of five ETs in diverse phylogenetic lineages was interpreted as evidence that the gene has been horizontally distributed among clones, presumably by bacteriophage-mediated transfer.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1672766-1195397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1672766-1967495,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1672766-1984738,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1672766-2184817,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1672766-2352822,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1672766-2425735,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1672766-2448875,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1672766-2504778,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1672766-2548171,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1672766-2553612,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1672766-2566595,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1672766-2659990,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1672766-2682245,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1672766-2698123,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1672766-2836707,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1672766-3009415,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1672766-3054779,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1672766-3076677,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1672766-3128449,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1672766-3282471,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1672766-3284952,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1672766-3286782,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1672766-3288161,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1672766-3293424,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1672766-3299086,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1672766-3320930,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1672766-3514452,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1672766-3926872,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1672766-6374381,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1672766-6999623,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1672766-7091960
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
88
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2668-72
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1672766-Bacterial Proteins,
pubmed-meshheading:1672766-Base Sequence,
pubmed-meshheading:1672766-Enzymes,
pubmed-meshheading:1672766-Europe,
pubmed-meshheading:1672766-Exotoxins,
pubmed-meshheading:1672766-Genes, Bacterial,
pubmed-meshheading:1672766-Genetic Variation,
pubmed-meshheading:1672766-Genotype,
pubmed-meshheading:1672766-Humans,
pubmed-meshheading:1672766-Membrane Proteins,
pubmed-meshheading:1672766-Molecular Sequence Data,
pubmed-meshheading:1672766-Oligonucleotide Probes,
pubmed-meshheading:1672766-Phylogeny,
pubmed-meshheading:1672766-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:1672766-Shock, Septic,
pubmed-meshheading:1672766-Streptococcal Infections,
pubmed-meshheading:1672766-Streptococcus pyogenes,
pubmed-meshheading:1672766-United States
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pubmed:year |
1991
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pubmed:articleTitle |
Streptococcus pyogenes causing toxic-shock-like syndrome and other invasive diseases: clonal diversity and pyrogenic exotoxin expression.
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pubmed:affiliation |
Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia 19104.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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