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rdf:type |
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lifeskim:mentions |
umls-concept:C0005456,
umls-concept:C0017337,
umls-concept:C0017710,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0041487,
umls-concept:C0108685,
umls-concept:C0205314,
umls-concept:C0205369,
umls-concept:C0332281,
umls-concept:C0439064,
umls-concept:C0439148,
umls-concept:C0441655,
umls-concept:C0521447,
umls-concept:C0679622,
umls-concept:C1521761
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pubmed:issue |
1
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pubmed:dateCreated |
1991-5-7
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pubmed:abstractText |
The structures of two remote glucocorticoid responsive units (GRUs) that cooperatively interact to promote cell-type specific glucocorticoid induction of rat tyrosine aminotransferase gene expression have been analyzed. DNAase I footprinting and gel mobility shift analyses reveal a complex array of contiguous and overlapping sites for cell type-specific DNA binding proteins. Apart from the glucocorticoid receptor, two liver-specific nuclear factors possess multiple binding sites in each of these GRUs: C/EBP and a newly identified liver-specific factor: HNF5. C/EBP possesses four binding sites in each GRU; a DNA-binding protein with similar binding specificity has been identified in fibroblasts; this protein could be related to AP-3. HNF5 possesses two binding sites in one GRU and four in the other. There are also HNF5 binding sites in numerous regulatory regions of other liver-specific genes. The interaction of HNF5 with DNA gives a characteristic DNAase I footprint with hypersensitive sites in the middle of the recognition sequence. Some of the C/EBP and HNF5 binding sites overlap in a conserved arrangement.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1672737-2121606,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/1672737-6540146
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0305-1048
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
11
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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