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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1991-5-3
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pubmed:abstractText |
Previously we have described (Hugo, P. et al., Int. Immunol. 1990. 2: 209) an immature CD4+CD8-CD3- thymocyte subset which is thought to be the counterpart of the CD4-CD8+CD3- subset. In this study we show that the ontogeny of these two subsets is parallel in fetal thymic organ culture. Extensive phenotypic characterization of CD4+CD8-CD3- cells reveals that they closely resemble CD4-CD8+CD3- thymocytes being: HSAhigh, Thy-1high, interleukin 2 receptor alpha chain negative, CD44-, H-2K+/-, CD5low, MEL-14low/intermediate, CD2+, LFA-1+ and MTS 35+. Finally, we show that the proportion of CD4+CD8-CD3- thymocytes is highly variable between mouse strains.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Mar
|
pubmed:issn |
0014-2980
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
835-8
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:1672651-Animals,
pubmed-meshheading:1672651-Antigens, CD3,
pubmed-meshheading:1672651-Antigens, CD8,
pubmed-meshheading:1672651-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:1672651-CD4-Positive T-Lymphocytes,
pubmed-meshheading:1672651-Cell Differentiation,
pubmed-meshheading:1672651-Flow Cytometry,
pubmed-meshheading:1672651-Mice,
pubmed-meshheading:1672651-Mice, Inbred Strains,
pubmed-meshheading:1672651-Organ Culture Techniques,
pubmed-meshheading:1672651-Receptors, Antigen, T-Cell,
pubmed-meshheading:1672651-Thymus Gland
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pubmed:year |
1991
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pubmed:articleTitle |
Characterization of immature CD4+CD8-CD3- thymocytes.
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pubmed:affiliation |
Department of Pathology and Immunology, Monash Medical School, Melbourne.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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