Source:http://linkedlifedata.com/resource/pubmed/id/16724832
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
2006-5-26
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| pubmed:abstractText |
A group of new 10mer linear peptides, designated culicinins A-D (1-4), was isolated from the fermentation broth of the entomopathogenic fungus Culicinomyces clavisporus, strain LL-12I252. The structures of the culicinins were determined by a combination of 2D NMR and MS analysis. The major compound, culicinin D (4), exhibited selective inhibitory activity against PTEN-negative MDA468 tumor cells. Studies on the 3D structure of 4 using NOE data and computer modeling revealed a dominant conformation of the right-handed helix.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0163-3864
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
69
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
736-41
|
| pubmed:dateRevised |
2007-11-15
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| pubmed:meshHeading |
pubmed-meshheading:16724832-Antineoplastic Agents,
pubmed-meshheading:16724832-Drug Screening Assays, Antitumor,
pubmed-meshheading:16724832-Humans,
pubmed-meshheading:16724832-Hypocreales,
pubmed-meshheading:16724832-Models, Chemical,
pubmed-meshheading:16724832-Molecular Structure,
pubmed-meshheading:16724832-New York,
pubmed-meshheading:16724832-Nuclear Magnetic Resonance, Biomolecular,
pubmed-meshheading:16724832-Oligopeptides,
pubmed-meshheading:16724832-Peptaibols,
pubmed-meshheading:16724832-Tumor Cells, Cultured
|
| pubmed:year |
2006
|
| pubmed:articleTitle |
Culicinin D, an antitumor peptaibol produced by the fungus Culicinomyces clavisporus, strain LL-12I252.
|
| pubmed:affiliation |
Wyeth Research, Pearl River, New York 10965, USA. heh@wyeth.com
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| pubmed:publicationType |
Journal Article
|