Linked Life Data

16724628

Source:http://linkedlifedata.com/resource/pubmed/id/16724628

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SubjectPredicateObjectContext
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pubmed-article:16724628pubmed:dateCreated2006-5-26lld:pubmed
pubmed-article:16724628pubmed:abstractTextRecent studies suggest that genetic polymorphism modulates immunoglobulin E (IgE)-mediated atopic reactions. Adenosine is an important local hormone influencing immune function and tissue reactivity; because adenosine concentration is regulated by adenosine deaminase (ADA), we have investigated the possible effect of ADA polymorphism on the relationship between IgE and positive prick test. A random sample of 160 schoolchildren from the population of Viterbo (Italy) were studied. Prick testing was performed with a panel of local allergens. Total IgE assay was performed according to standard clinical procedure. ADA phenotype was determined according to Spencer et al. A highly significant correlation between prick test and IgE was observed. However, the strength of correlation was moderate (eta2 = 0.16), indicating that positive prick testing depends on other variables besides IgE. The relationship between IgE and positive prick testing is stronger in carriers of ADA*2 allele than in ADA*1/*1 subjects. Also, sensitivity and predictive values are higher in ADA*2 carriers than in homozygous ADA*1/*1 children. The data suggest that the effect of IgE level on local reactivity is influenced by ADA polymorphism; at low level of IgE, the presence of the ADA*2 allele seems to protect from positive prick testing.lld:pubmed
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pubmed-article:16724628pubmed:authorpubmed-author:BottiniNunzio...lld:pubmed
pubmed-article:16724628pubmed:authorpubmed-author:RonchettiFran...lld:pubmed
pubmed-article:16724628pubmed:authorpubmed-author:Gloria-Bottin...lld:pubmed
pubmed-article:16724628pubmed:authorpubmed-author:AmmendolaLeon...lld:pubmed
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pubmed-article:16724628pubmed:volume27lld:pubmed
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pubmed-article:16724628pubmed:pagination115-8lld:pubmed
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pubmed-article:16724628pubmed:articleTitleAdenosine deaminase polymorphism and the relationship of total immunoglobulin E with skin prick test: a study on school children.lld:pubmed
pubmed-article:16724628pubmed:affiliationDepartment of Biopathology and Imaging Diagnostics, University of Rome Tor Vergata, Italy. gloria@med.uniroma2.itlld:pubmed
pubmed-article:16724628pubmed:publicationTypeJournal Articlelld:pubmed
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