16723593

Source:http://linkedlifedata.com/resource/pubmed/id/16723593

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0040935, umls-concept:C0076110, umls-concept:C0205210, umls-concept:C0205460, umls-concept:C0205474, umls-concept:C0332325, umls-concept:C0370215, umls-concept:C1521991, umls-concept:C1880022
pubmed:issue	6
pubmed:dateCreated	2006-5-25
pubmed:databankReference	http://linkedlifedata.com/resource/pubmed/xref/GENBANK/DQ060522
pubmed:abstractText	We have characterized a new clinical strain of Trichophyton rubrum highly resistant to terbinafine but exhibiting normal susceptibility to drugs with other mechanisms of action. Resistance to terbinafine in this strain is caused by a missense mutation in the squalene epoxidase gene leading to the amino acid substitution F397L.
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/16723593-10865915, http://linkedlifedata.com/resource/pubmed/commentcorrection/16723593-11053904, http://linkedlifedata.com/resource/pubmed/commentcorrection/16723593-11136808, http://linkedlifedata.com/resource/pubmed/commentcorrection/16723593-12058731, http://linkedlifedata.com/resource/pubmed/commentcorrection/16723593-12160856, http://linkedlifedata.com/resource/pubmed/commentcorrection/16723593-12425880, http://linkedlifedata.com/resource/pubmed/commentcorrection/16723593-12499173, http://linkedlifedata.com/resource/pubmed/commentcorrection/16723593-12824352, http://linkedlifedata.com/resource/pubmed/commentcorrection/16723593-12932235, http://linkedlifedata.com/resource/pubmed/commentcorrection/16723593-14576134, http://linkedlifedata.com/resource/pubmed/commentcorrection/16723593-14638499, http://linkedlifedata.com/resource/pubmed/commentcorrection/16723593-14657630, http://linkedlifedata.com/resource/pubmed/commentcorrection/16723593-15504870, http://linkedlifedata.com/resource/pubmed/commentcorrection/16723593-15682641, http://linkedlifedata.com/resource/pubmed/commentcorrection/16723593-15980358, http://linkedlifedata.com/resource/pubmed/commentcorrection/16723593-8834895, http://linkedlifedata.com/resource/pubmed/commentcorrection/16723593-9143330, http://linkedlifedata.com/resource/pubmed/commentcorrection/16723593-9161422
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0315061
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Antifungal Agents, http://linkedlifedata.com/resource/pubmed/chemical/Ergosterol, http://linkedlifedata.com/resource/pubmed/chemical/Naphthalenes, http://linkedlifedata.com/resource/pubmed/chemical/Squalene Monooxygenase, http://linkedlifedata.com/resource/pubmed/chemical/terbinafine
pubmed:status	MEDLINE
pubmed:month	Jun
pubmed:issn	0066-4804
pubmed:author	pubmed-author:FavreBertrandB, pubmed-author:FieldingCeri ACA, pubmed-author:HofbauerBettinaB, pubmed-author:LeitnerIngridI, pubmed-author:OsborneColin SCS, pubmed-author:RyderNeil SNS
pubmed:issnType	Print
pubmed:volume	50
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	2234-6
pubmed:dateRevised	2009-11-18
pubmed:meshHeading	pubmed-meshheading:16723593-Amino Acid Substitution, pubmed-meshheading:16723593-Antifungal Agents, pubmed-meshheading:16723593-Base Sequence, pubmed-meshheading:16723593-Cloning, Molecular, pubmed-meshheading:16723593-Colony Count, Microbial, pubmed-meshheading:16723593-Drug Resistance, Fungal, pubmed-meshheading:16723593-Ergosterol, pubmed-meshheading:16723593-Humans, pubmed-meshheading:16723593-Microbial Sensitivity Tests, pubmed-meshheading:16723593-Molecular Sequence Data, pubmed-meshheading:16723593-Naphthalenes, pubmed-meshheading:16723593-Sequence Analysis, DNA, pubmed-meshheading:16723593-Squalene Monooxygenase, pubmed-meshheading:16723593-Trichophyton
pubmed:year	2006
pubmed:articleTitle	Biological, biochemical, and molecular characterization of a new clinical Trichophyton rubrum isolate resistant to terbinafine.
pubmed:affiliation	Infectious Diseases, Novartis Institutes for BioMedical Research, Inc., Cambridge, MA 02139, USA. colin.osborne@novartis.com
pubmed:publicationType	Journal Article, Comparative Study