rdf:type |
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lifeskim:mentions |
|
pubmed:issue |
29-30
|
pubmed:dateCreated |
2006-7-3
|
pubmed:abstractText |
The immunogenicity and reactogenicity, in British schoolchildren, of the newly introduced Danish-SSI 1331 BCG vaccine was compared with that of the previously used Glaxo-Evans 1077 BCG vaccine. Interferon-gamma (IFN-gamma) response to M. tuberculosis purified protein derivative (M.tb PPD) in a 6-day whole blood assay and delayed type hypersensitivity (DTH) to tuberculin PPD were determined before and 1 year after receiving BCG or no vaccination. Scar size was measured 1 year after vaccination. There was no evidence of a difference in immunogenicity (IFN-gamma and DTH conversion rates) but evidence of lower reactogenicity (scar size) with Danish-SSI 1331 compared to Glaxo-Evans 1077 vaccines.
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pubmed:grant |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jul
|
pubmed:issn |
0264-410X
|
pubmed:author |
pubmed-author:Ben-SmithAnneA,
pubmed-author:BlitzRoseR,
pubmed-author:BransonKeithK,
pubmed-author:DockrellHazel MHM,
pubmed-author:FinePaul E MPE,
pubmed-author:FloydSianS,
pubmed-author:Gorak-StolinskaPatriciaP,
pubmed-author:LalorMaeve KMK,
pubmed-author:LukeSarahS,
pubmed-author:NazarethBernadetteB,
pubmed-author:StensonSallyS,
pubmed-author:WeirRosemary ERE
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pubmed:issnType |
Print
|
pubmed:day |
17
|
pubmed:volume |
24
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
5726-33
|
pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:16723176-BCG Vaccine,
pubmed-meshheading:16723176-Child,
pubmed-meshheading:16723176-Cicatrix,
pubmed-meshheading:16723176-Denmark,
pubmed-meshheading:16723176-Great Britain,
pubmed-meshheading:16723176-Humans,
pubmed-meshheading:16723176-Hypersensitivity, Delayed,
pubmed-meshheading:16723176-Interferon-gamma,
pubmed-meshheading:16723176-Mycobacterium tuberculosis,
pubmed-meshheading:16723176-Tuberculin,
pubmed-meshheading:16723176-Tuberculin Test,
pubmed-meshheading:16723176-Tuberculosis, Pulmonary,
pubmed-meshheading:16723176-Vaccination
|
pubmed:year |
2006
|
pubmed:articleTitle |
Immunogenicity of Danish-SSI 1331 BCG vaccine in the UK: comparison with Glaxo-Evans 1077 BCG vaccine.
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pubmed:affiliation |
London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, and Redbridge Primary Care Trust, Goodmayes Hospital, Essex, UK.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Research Support, Non-U.S. Gov't
|