Linked Life Data

16723116

Source:http://linkedlifedata.com/resource/pubmed/id/16723116

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2006-8-22
pubmed:abstractText
Nidus Vespae is the honeycomb of Polistes Olivaceous (De Geer), P. Japonicus Saussure, and Parapolybiavaria Fabricius. It is known to have a number of pharmacological effects, including antimicrobial, anti-inflammatory, anti-virus, anti-tumor and anesthetic properties. The present study evaluated the antimicrobial activity and acid inhibition properties of extracts and chemical fractions of Nidus Vespae. The raw material was first extracted using 95% ethanol/water. Subsequent fractions were prepared from this extract using cyclohexane/ethyl acetate, petroleum ether/ethyl acetate, and chloroform/methanol. For the antimicrobial activity assays, minimum inhibitory concentrations (MIC) and minimum bactericidal concentrations (MBC) were determined using the microdilution method. The chloroform/methanol (Chl/MeOH) fraction showed the highest antibacterial activities with a MIC of 8-16mg/ml and an MBC of 16-32mg/ml. In addition, the extract and chemical fractions of Nidus Vespae showed a remarkable capacity for inhibiting the acid production of common oral bacteria at sub-MIC concentrations. Sub-MIC levels of the petroleum ether/ethyl acetate fraction significantly inhibited acid production by Streptococcus mutans ATCC 25175. The significant antiacidogenic activity demonstrated by Nidus Vespae shows it to be a promising source of novel anticariogenic agents.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
D
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0003-9969
pubmed:author
pubmed:issnType
Print
pubmed:volume
51
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
804-13
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Effects of Nidus Vespae extract and chemical fractions on the growth and acidogenicity of oral microorganisms.
pubmed:affiliation
Key Laboratory for Oral Biomedical Engineering Ministry of Education, Chengdu, China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't